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The Effect Of E-Cigarette Vape On Oral Cell Proliferation Using 3d Spheroids As A Preclinical Model, Vikram Chinnaiyan
The Effect Of E-Cigarette Vape On Oral Cell Proliferation Using 3d Spheroids As A Preclinical Model, Vikram Chinnaiyan
Honors Undergraduate Theses
E-cigarettes have recently become increasingly popular, especially amongst middle and high school students. Although they are marketed as safer alternatives to tobacco cigarettes, they produce toxic metals and carcinogenic nitrosamines. This thesis studies the effects of e-cigarette aerosol on the growth and proliferation of oral epithelial cells because the consequences of vaping, including a potential risk for aberrant growth leading to cancer, are not well understood. Cells were grown in matrigel, causing the formation of three-dimensional spheroids modeling the physiological architecture of the oral epithelium. Those spheroids were chronically exposed to vape with different treatment conditions to study the functional …
Serotonin's Proliferative Effects On Lung Cancer Cell Lines, Jessy K. Ntabo
Serotonin's Proliferative Effects On Lung Cancer Cell Lines, Jessy K. Ntabo
Honors Undergraduate Theses
Serotonin has been widely explored in the brain. Recently, there have been new findings on how serotonin works in the periphery. Serotonin is introduced to the periphery by the enterochromaffin cells and metabolized by the liver and lung. Studies have shown that serotonin plays a role in controlling lung cancer. However, the mechanism by which it initiates tumor formation has not been fully explored. Cell viability was measured in several lung adenocarcinoma cell lines treated with serotonin to study this effect. In GFP-labelled cells, fluorescence intensity was measured for quantification of cell viability. Our data showed an overall increase in …
The Response Of Satellite Glial Cells To P2x7 Receptor Activation, Christina D. Kursewicz
The Response Of Satellite Glial Cells To P2x7 Receptor Activation, Christina D. Kursewicz
Honors Undergraduate Theses
Satellite glial cells (SGCs) surround the cell bodies of neurons of the peripheral nervous system, including those of the sensory ganglia. Their close apposition to the neuronal soma allows for bi-directional communication between neurons and SGCs, which are thought to regulate neuronal activity. After nerve injury, SGCs in the dorsal root ganglia contribute to neuropathic pain. Although the mechanisms are not fully understood, SGCs show increased coupling via gap junctions, and communicate with the neuron via bi-directional purinergic signaling after nerve injury. The increased coupling between SGCs and neurons may have implications for chronic pain following peripheral nerve injury. In …