Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Genetics and Genomics (3)
- Medicine and Health Sciences (3)
- Animal Sciences (2)
- Biochemistry, Biophysics, and Structural Biology (2)
- Diseases (2)
-
- Genetics (2)
- Immunology and Infectious Disease (2)
- Microbiology (2)
- Agriculture (1)
- Animal Diseases (1)
- Biochemistry (1)
- Biology (1)
- Biomedical Engineering and Bioengineering (1)
- Cell Biology (1)
- Cell and Developmental Biology (1)
- Engineering (1)
- Environmental Microbiology and Microbial Ecology (1)
- Genetic Phenomena (1)
- Marine Biology (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Microbial Physiology (1)
- Molecular Biology (1)
- Neuroscience and Neurobiology (1)
- Oncology (1)
- Other Animal Sciences (1)
- Other Immunology and Infectious Disease (1)
- Other Microbiology (1)
- Parasitic Diseases (1)
- Keyword
-
- Air particulate matter (1)
- Alder (1)
- Arteritis (1)
- Auxin (1)
- Bioinformatics (1)
-
- Breast cancer (1)
- Bromodomain (1)
- CLUE (1)
- Chronic bronchitis (1)
- E. coli (1)
- Environmental survey (1)
- Fungal infections (1)
- Gene editing (1)
- Heat resistance (1)
- Histopathology (1)
- Horse allergen (1)
- Indoor riding arena (1)
- Inducible expression (1)
- LacI (1)
- Lungworm (1)
- Microbial community (1)
- Microbiome (1)
- Molecular biology (1)
- New England (1)
- Nitrogen fixation (1)
- Opportunistic fungi (1)
- Opportunistic infections (1)
- Parasitology (1)
- Prolactin (1)
- Pseudonodules (1)
Articles 1 - 9 of 9
Full-Text Articles in Life Sciences
Engineering Thermostable Regulators For Inducible Gene Expression In Thermophiles, Connor M. Joyce
Engineering Thermostable Regulators For Inducible Gene Expression In Thermophiles, Connor M. Joyce
Honors Theses and Capstones
Thermophilic bacteria have attracted research interest due to their ability to grow at high temperatures ranging from 45 °C to 75 °C with some extreme thermophiles able to survive nearly boiling temperatures. They are valuable sources of thermostable biocatalysts and many have great potential as industrial hosts for biofuel production because fermentation at high temperatures has advantages such as reduced processing costs and lower risk of contamination compared with mesophilic bacteria. For example, some Geobacillus species has been shown to have high solvent tolerance, making them good candidates as host for alcohol production. To develop them as industrial hosts, large …
A Survey Of Opportunistic Fungi In The Portsmouth, Nh Region, Chloe E. Richard
A Survey Of Opportunistic Fungi In The Portsmouth, Nh Region, Chloe E. Richard
Honors Theses and Capstones
Opportunistic mycoses are caused by ubiquitous fungi that we encounter daily. This study identified the most common opportunistic fungi in a local area during the current winter season. A survey of fungi was conducted in the Portsmouth, New Hampshire region by taking environmental samples from both indoor and outdoor locations. The samples were then cultured and identified using colony morphology, microscopic characteristics, and biochemical testing. Despite the cold weather, the results showed that fungal species are still prevalent outdoors, with the most variation in single samples coming from areas with exposed soil and decaying vegetation, while less fungal presence was …
Effects Of The Air Quality In Equine Stable Environments On The Respiratory Health And Allergy Response Of Human Personnel: A Review, Maeve Hannah Perrin
Effects Of The Air Quality In Equine Stable Environments On The Respiratory Health And Allergy Response Of Human Personnel: A Review, Maeve Hannah Perrin
Honors Theses and Capstones
Many studies have evaluated the impact of poor stable air quality on equine respiratory health and respiratory illness in horses. Many factors contribute to poor air quality conditions in the equine stable environment, including ventilation rates, humidity levels, presence of noxious gases, rate of fungal spore production, and level of airborne organic and inorganic dust particles. While the implications of poor air quality for equine health are well-documented, far less is known about how air quality impacts human stable personnel. This literature review seeks to evaluate the implications of poor equine stable air quality on the respiratory health and allergic …
Roles Of Non-Frankia Bacteria In Root Nodule Formation And Function In Alnus Sp., Kelsey Christine Mercurio
Roles Of Non-Frankia Bacteria In Root Nodule Formation And Function In Alnus Sp., Kelsey Christine Mercurio
Honors Theses and Capstones
Plant roots are home to a wide variety of beneficial microbes; understanding and optimizing plant-microbe interactions may be critical to enhance global food security in a sustainable, equitable way. With the help of their nitrogen-fixing bacterial partner, Frankia, actinorhizal plants form symbiotic root nodules and play important roles in agroforestry and land reclamation. However, Frankia does not live alone in nodules, and the other microbial residents may contribute to nodule formation and function. We collected root nodules from alder trees (Alnus sp.) in 2018 and 2019, then isolated DNA and individual bacterial strains to characterize the nodule microbial …
Mimicking The Effect Of Prolactin On Stat3/Stat5 Activity In Breast Cancer, Jennifer N. Barbuto, Sarah R. Walker
Mimicking The Effect Of Prolactin On Stat3/Stat5 Activity In Breast Cancer, Jennifer N. Barbuto, Sarah R. Walker
Honors Theses and Capstones
Signal transducers and activators of transcription (STAT) 3 and 5 are commonly constitutively activated in breast cancer. STAT5 can outcompete STAT3 and reduce cell proliferation and metastasis. STAT5 activation is stimulated by prolactin, a natural hormone that can be harmful at high levels. The aim of this study is to identify some possible previously developed drugs that mimic the effect of prolactin and STAT5 without the added risk in MDA-MB231 breast cancer cells. Using the CLUE database query app and STAT5 up- and downregulation signatures, three drugs (X, K, and M) were chosen based on their similarity in signatures to …
Occurrence Of Pulmonary Arteritis With Lungworm Infections In Gray Seals From New England, 2013-2020, Jillian R. Broadhurst, Inga Sidor Dvm, Ms, Dacvp
Occurrence Of Pulmonary Arteritis With Lungworm Infections In Gray Seals From New England, 2013-2020, Jillian R. Broadhurst, Inga Sidor Dvm, Ms, Dacvp
Honors Theses and Capstones
Gray seals (Halichoerus grypus) are a common pinniped species in New England coastal waters. Parasitic infection is an important cause of mortality for this species, and lungworm species are frequently implicated in cases of respiratory infection, especially in pups and weanling seals. The most common of these is Otostrongylus circumlitus, a large nematode found in the bronchi and bronchioles of affected seals. The full life cycle is unknown but its presence in lungs and sometimes pulmonary arteries suggests that migration via arterial circulation occurs. Signs and microscopic findings are widely variable; our cases included dyspnea, bloody mucoid …
Factor Fiction? Identifying A Putative Toxoplasma Gondii Transcriptional Complex, Julia M. Paquette
Factor Fiction? Identifying A Putative Toxoplasma Gondii Transcriptional Complex, Julia M. Paquette
Honors Theses and Capstones
Toxoplasma gondii is a highly prevalent protozoan parasite that is estimated to infect 30-50% of the global population, though there is no treatment for chronic infection and current treatments for acute infection may have serious side effects. Transcription is a tightly regulated process in T. gondii, allowing the parasite to successfully invade and replicate within host cells, and it is thus a promising avenue to study gene regulation and to investigate possible novel therapeutics. In our lab’s previous research, a TFIID-like complex was identified in T. gondii and found to be associated with the parasite specific bromodomain protein BDP3. …
Expanding On The Involvement Of Primary Cilia In Neurological Function Through Observing Eeg/Emg Changes In Different Genotypic Mice, Gabriella M. Palermo
Expanding On The Involvement Of Primary Cilia In Neurological Function Through Observing Eeg/Emg Changes In Different Genotypic Mice, Gabriella M. Palermo
Honors Theses and Capstones
Primary cilia have been known to regulate neurological functions, as primary cilia exist on astrocytes and neurons in the mature brain. More is being discovered about primary cilia and their role in the vertebrate nervous system; however, little is known about their functions and molecular pathways in the mature brain. There also lacks methods of diagnosis for primary cilia-related defects and diseases. The purpose of this project was to provide more information on the involvement of cilia in the neurological functions and offer a potential means for diagnosis of cilia-related disorders by comparing the EEG and EMG signals of wildtype …
Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood
Sars-Cov-2: An Investigation On Mutagenicity And Its Effects On Infectivity And Mortality, Tyler Elliott Silverwood
Honors Theses and Capstones
SARS-CoV-2, the etiological agent of the COVID-19 pandemic, has rapidly become a worldwide public health concern. Classified as a betacoronavirus, it is the third human coronavirus (HCoV) to emerge in the 21st century that causes severe disease, alongside SARS-CoV and MERS-CoV. The genome consists of open reading frames encoding accessory proteins and four structural proteins, including the spike protein which is a key determinant of host cell tropism. Mutations within the genome, particularly the spike gene, have been linked in-vitro to increased binding affinity to the human receptor angiotensin-converting enzyme 2 (hACE2), increased fitness in human hosts, and immune evasion. …