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The Influence Of Extracellular-Regulated Kinases (Erks) On Granulosa Cell Fate In The Bovine Follicle, Nicolette M. Schwab
The Influence Of Extracellular-Regulated Kinases (Erks) On Granulosa Cell Fate In The Bovine Follicle, Nicolette M. Schwab
Honors Theses and Capstones
Each year, infertility in cows costs the dairy industry over $400 million. This project is focused on the onset of follicular atresia in cows; the process by which the egg-bearing follicles die prematurely and can lead to infertility. The cellular mechanisms that influence programmed cell death, or apoptosis, of bovine granulosa cells (bGCs) within follicles are being investigated. In general, the extra-cellular regulated kinases (ERKs) are intracellular signaling proteins believed to influence the proliferation, survival, and differentiation of cells. In the context of follicular atresia, however, the relationship between the onset of apoptosis of bGCs and the effects of ERKs …