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Full-Text Articles in Life Sciences
Cd46 Interaction With Adenovirus Type 64, A Causative Agent For Viral Pink Eye, Hanglin (Henry) Zhu
Cd46 Interaction With Adenovirus Type 64, A Causative Agent For Viral Pink Eye, Hanglin (Henry) Zhu
Honors Theses
Human adenovirus type 64 (Ad64) is a causative agent of contagious viral pink eye. We do not understand why Ad64 causes eye infections. One likely reason is the presence of a receptor molecule on the exposed surface of eye cells, but not other cells. Ad64 binds to a protein called CD46 on the cell surface. We aim to visualize how CD46 binds to the surface of Ad64. I mixed the extracellular portion of CD46 with purified Ad64 virus, then visualized it using negative stain transmission electron microscopy. In order to gain insight into how the virus binds CD46, we used …
Cell Volume As A Determinant Of Virus-Mediated Population Growth In Ciliates, Jace Miller, John Paul Delong Phd
Cell Volume As A Determinant Of Virus-Mediated Population Growth In Ciliates, Jace Miller, John Paul Delong Phd
Honors Theses
Many protists and other small aquatic organisms consume virus particles, a behavior known as virovory. Some species of protists, such as the ciliate Halteria grandinella, can grow and divide using viruses as their sole food source. Other ciliate species have previously been shown to consume large quantities of viral particles, but it is unclear if they are able to support population growth with viruses alone. Because large ciliates have a higher energy demand, we hypothesize that they will be unable to support population growth on a virus-only diet. We fed nine ciliate species a diet of chloroviruses and found …
Assessment Of Virus-Induced Myocarditis In Human Heart Tissue Samples, Gabriel Galeotos
Assessment Of Virus-Induced Myocarditis In Human Heart Tissue Samples, Gabriel Galeotos
Honors Theses
The heart is a major organ whose function is to transport nutrients and waste throughout the body. This organ can become infected by pathogens, such as viruses, bacteria, or parasites. Infection of the middle heart layer, or myocardium, is often caused by a viral agent. This disease has three stages: viral infiltration, adaptive immune system activation, and finally either viral clearance or cardiac cell remodeling. During this process the immune system will begin to secrete cytokines, which are signaling molecules that alert other members of the immune pathways, and also participate in cardiac remodeling. Evaluating the correlation between the cytokine …