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Full-Text Articles in Life Sciences
Synthesis Of An Ideal Inhibitor For The Lpxc Enzyme, Taejun Lee
Synthesis Of An Ideal Inhibitor For The Lpxc Enzyme, Taejun Lee
Honors Theses
Due to the growing need of antibiotics in modern day medicine, this study attempts to apply a method of medicinal chemistry that would create a novel inhibitor for a lesser known target of gram negative bacteria, the LpxC enzyme. This study proposes that a synthetic plan which consists of combining components of different molecules would create a more effective inhibitor. These components include a binding group for the active site of the enzyme, a hydrophobic chain which has been shown to interact with an allosteric site on the LpxC enzyme, and the isoxazoline ring which interacts with the zinc ion. …
An Investigation Into The Relationship Between The Activation Of Amp Kinase And The Acetylation Of Microtubules, Jessica Sarrantonio
An Investigation Into The Relationship Between The Activation Of Amp Kinase And The Acetylation Of Microtubules, Jessica Sarrantonio
Honors Theses
Microtubules, or cytoskeletal polymers composed of the protein tubulin, form long hollow tubes in the cell and are responsible for many critical roles. Previous research has shown that depletion of ATP causes microtubules to become stable, i.e. resistant to depolymerization. It has also been shown that enhanced stability of microtubules correlates with increased tubulin acetylation, a common microtubule posttranslation modification. ATP-depletion is a severe metabolic stressor, and as such, we expect that this treatment would activate AMP kinase, an enzyme deemed the “master regulator” of metabolism. When activated by a variety of stressors, this enzyme can initiate a program of …