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Characterization Of Embryonic Stem Cell-Differentiated Cells As Mesenchymal Stem Cells, Rachael N. Kuehn
Characterization Of Embryonic Stem Cell-Differentiated Cells As Mesenchymal Stem Cells, Rachael N. Kuehn
Honors Theses
Embryonic stem cells (ESCs), due to their ability to differentiate into different cell types while still maintaining a high proliferation capacity, have been considered as a potential cell source in regenerative medicine. However, current ESC differentiation methods are low yielding and create heterogeneous cell populations. If transplanted in the human body, differentiated ESCs could be rejected by the immune system, form tumors, or may not function normally within the human body. On the other hand, mesenchymal stem cells (MSCs), a type of adult stem cell typically derived from bone marrow, have proved to be excellent candidates in clinical applications due …
Activation Of Nf-Κb Transcription Factor During In Vitro Differentiation Of Mouse Embryonic Stem Cells, Natalya A. Ortolano
Activation Of Nf-Κb Transcription Factor During In Vitro Differentiation Of Mouse Embryonic Stem Cells, Natalya A. Ortolano
Honors Theses
Embryonic stem cells (ESCs) are a promising cell source for regenerative medicine. However, recent studies indicated that ESCs and ESC-derived cells (ESC-DCs) lack functional innate immunity against various pathogens and inflammatory cytokines. This presents a barrier to clinical application, as ESC-DCs would be placed in a wound site and exposed to pathogens and inflammatory cytokines. Using mouse ESCs (mESCs) as a model, we recently demonstrated that they are deficient in expressing type I interferons (IFN) and inflammatory cytokines. To determine the molecular basis for this finding, this study examined the activation state of nuclear factor-κB (NF-κB), a transcription factor that …