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Differentiation Of Human Embryonic Stem Cell (Hesc) Derived Pyramidal Neurons, Eagan Jacqueline
Differentiation Of Human Embryonic Stem Cell (Hesc) Derived Pyramidal Neurons, Eagan Jacqueline
Honors Scholar Theses
The mammalian cerebral neocortex is a complex six-layered structure containing multiple types of neurons. Pyramidal neurons of the neocortex are formed during development in an inside-out manner, by which deep layer (DL) neurons are generated first, and upper layer (UL) neurons are generated last. Neurons within the six-layered neocortex express unique markers for their position, showing whether they are subplate, deep layer, upper layer, or Cajal-Retzius neurons. The sequential generation of cortical layers, which exists in vivo, has been partially recapitulated in vitro by differentiation of mouse embryonic stem cells (Gaspard et al., 2008) and human embryonic stem cells (hESC) …