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Full-Text Articles in Life Sciences
Human Skeletal Muscle Feed Arteries: Evidence Of Regulatory Potential, S. J. Ives, R. H. I. Andtbacka, Song-Young Park, A. J. Donato, J. R. Gifford, R. D. Noyes, L. A. Lesniewski, R. S. Richardson
Human Skeletal Muscle Feed Arteries: Evidence Of Regulatory Potential, S. J. Ives, R. H. I. Andtbacka, Song-Young Park, A. J. Donato, J. R. Gifford, R. D. Noyes, L. A. Lesniewski, R. S. Richardson
Health and Kinesiology Faculty Publications
Aim
Recently, it has been recognized that human skeletal muscle feed arteries can be harvested during exploratory surgery for melanoma. This approach provides vessels for in vitro study from a wide spectrum of relatively healthy humans. Although, the regulatory role of skeletal muscle feed arteries in rodent models has been documented, whether such vessels in humans possess this functionality is unknown.
Methods
Therefore, skeletal muscle feed arteries (~950 μm OD) from 10 humans (48 ± 4, 27–64 years) were studied using pressure myography. Vessel function was assessed using potassium chloride (KCl), phenylephrine (PE), acetylcholine (ACh) and sodium nitroprusside (SNP) concentration–response …