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Analysis Of Intracellular Calcium Events In Hypothalamic Neurons, Samantha Kolowrat
Analysis Of Intracellular Calcium Events In Hypothalamic Neurons, Samantha Kolowrat
Graduate College Dissertations and Theses
The paraventricular nucleus of the hypothalamus (PVN) plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic activity, cardiovascular system and stress responses.1,2 This brain region is primarily controlled by GABA and glutamate inputs from the peri-PVN region.3 Two significant modulators of these GABA-glutamate systems are Angiotensin II (Ang II) and brain derived neurotrophic factor (BDNF). It has been postulated that BDNF and Ang II signaling rely on each other via cross-activation of their receptors and by activation of the non-selective cation channel, the transient receptor channel type C3 (TRPC3).This thesis aims to study changes in intracellular calcium levels …