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Full-Text Articles in Life Sciences
Manipulation Of Prenatal Hormones And Dietary Phytoestrogens During Adulthood Alter The Sexually Dimorphic Expression Of Visual Spatial Memory, Edwin D. Lephart, Trent D. Lund
Manipulation Of Prenatal Hormones And Dietary Phytoestrogens During Adulthood Alter The Sexually Dimorphic Expression Of Visual Spatial Memory, Edwin D. Lephart, Trent D. Lund
Faculty Publications
In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit higher performance levels compared to females (a difference attributed to sex steroid hormonal influences). Based upon the results from our companion investigation, this study examined the influence of prenatal sex steroid hormone manipulations on VSM in adulthood, as assessed in the radial arm maze. Additionally, the influence of dietary soy phytoestrogens (i.e., the presence of high or low estrogen-like compounds present in the animal's diet) on VSM was examined in combination with the prenatal hormonal manipulations. Results: Radial arm maze performance on a phytoestrogen-rich diet: 1) females treated …
Visual Spatial Memory Is Enhanced In Female Rats (But Inhibited In Males) By Dietary Soy Phytoestrogens, Edwin D. Lephart, Trent D. Lund, Timothy W. West, Lilyan Y. Tian, Lihong H. Bu, Daniel L. Simmons, Kenneth Setchell, Herman Adlercreutz
Visual Spatial Memory Is Enhanced In Female Rats (But Inhibited In Males) By Dietary Soy Phytoestrogens, Edwin D. Lephart, Trent D. Lund, Timothy W. West, Lilyan Y. Tian, Lihong H. Bu, Daniel L. Simmons, Kenneth Setchell, Herman Adlercreutz
Faculty Publications
In learning and memory tasks, requiring visual spatial memory (VSM), males exhibit superior performance to females (a difference attributed to the hormonal influence of estrogen). This study examined the influence of phytoestrogens (estrogen-like plant compounds) on VSM, utilizing radial arm-maze methods to examine varying aspects of memory. Additionally, brain phytoestrogen, calbindin (CALB), and cyclooxygenase-2 (COX-2) levels were determined. Results: Female rats receiving lifelong exposure to a high-phytoestrogen containing diet (Phyto-600) acquired the maze faster than females fed a phytoestrogen-free diet (Phyto-free); in males the opposite diet effect was identified. In a separate experiment, at 80 days-of-age, animals fed the Phyto-600 …
Comparative Phylogeography Of Mesoamerican Highland Rodents: Concerted Versus Independent Response To Past Climatic Fluctuations, Duke S. Rogers, Jack Sullivan, Elizabeth Arellano
Comparative Phylogeography Of Mesoamerican Highland Rodents: Concerted Versus Independent Response To Past Climatic Fluctuations, Duke S. Rogers, Jack Sullivan, Elizabeth Arellano
Faculty Publications
The phylogeography of Sumichrast's harvest mouse (Reithrodontomys sumichrasti) was examined through maximumlikelihood and parsimony analyses of 1,130 bp of mitochondrial Cytochrome b sequence data from 43 individuals. The phylogeography of this Middle American highland forest-dwelling species was compared to that previously published for the codistributed Aztec deer mouse complex (Peromyscus aztecus/Peromyscus hylocetes complex) in order to test competing hypotheses of concerted versus independent responses of codistributed forms to past climatic fluctuations. Qualitatively, there were strong similarities in the phylogeographic patterns of the two groups, yet there were also areas of incongruence. Likelihood-ratio tests (Kishino-Hasegawa-Templeton and parametric bootstrap tests) indicated that …
Restoration Of Fish Habitat In The Provo River: A Multispecies Approach, Mark C. Belk
Restoration Of Fish Habitat In The Provo River: A Multispecies Approach, Mark C. Belk
Faculty Publications
Historically, the Provo river, located in Utah and Wasatch Cos., Utah, was a clear-flowing stream with headwaters in the western edge of the Uinta mountains that emptied into Utah Lake near Provo, Utah. The river had a wide flood plain and a braided channel, especially in the Heber valley and Utah valley areas. Diversion of water and construction of water storage facilities began in the late 1800's and intensified in the 1900's. Deer Creek reservoir was built in the 1950's and diking and channelization continued until the construction of Jordanelle reservoir in the late 1980's. The Provo River Restoration Project, …
Human Immunodeficiency Virus Type 1 Quasi Species That Rebound After Discontinuation Of Highly Active Antiretroviral Therapy Are Similar To The Viral Quasi Species Present Before Initiation Of Therapy, Keith A. Crandall, Hiromi Imamichi, Ven Natarajan, Min Kang Jiang, Robin L. Dewar, Steve Berg, Arunasri Gaddam, Marjorie Bosche, Julie A. Metcalf, Richard T. Davey Jr., H. Clifford Lane
Human Immunodeficiency Virus Type 1 Quasi Species That Rebound After Discontinuation Of Highly Active Antiretroviral Therapy Are Similar To The Viral Quasi Species Present Before Initiation Of Therapy, Keith A. Crandall, Hiromi Imamichi, Ven Natarajan, Min Kang Jiang, Robin L. Dewar, Steve Berg, Arunasri Gaddam, Marjorie Bosche, Julie A. Metcalf, Richard T. Davey Jr., H. Clifford Lane
Faculty Publications
In an effort to identify the sources of the viruses that emerge after discontinuation of therapy, analyses of human immunodeficiency virus (HIV) quasi species were done for 3 patients with sustained levels of HIV RNA of <50 copies/mL for 1-3 years. The sequences found in the rebounding plasma virus were closely related to those of the actively replicating form of viruses present before the initiation of combination therapy. All quasi species found in the rebounding plasma virus were also present in proviral DNA, cell-associated RNA in peripheral blood mononuclear cells (PBMC), and virion RNA derived from PBMC coculture during periods when plasma HIV RNA levels were <50 copies/mL. These findings suggest that the rapid resurgence of plasma viremia observed after discontinuation of therapy and the viruses cocultured from PBMC are derived from a relatively stable pool of the replicating form of virus rather than from activation of a previously latent pool.