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Modulating Adipogenesis: Key Role Of Ras-Related Protein Rab5 And Its Effectors, Yongjun Huang
Modulating Adipogenesis: Key Role Of Ras-Related Protein Rab5 And Its Effectors, Yongjun Huang
FIU Electronic Theses and Dissertations
The formation of adipocytes is a complicated process in which insulin and IGF-1 signaling pathways and numerous transcription factors control the conversion of precursor cells to mature fat cells. The Rab5 protein acts as a rate-limiting protein during receptor-mediated endocytosis by switching between a GDP-bound inactive form and a GTP-bound active form. The inactivation and activation of Rab5 are regulated by several Rab5 GTPase activating proteins (GAPs) and Rab5 guanine nucleotide exchange factors (GEFs), respectively.
This dissertation demonstrated that the activity of the small GTPase Rab5 and its regulators are essential for the differentiation of 3T3-L1 pre-adipocytes. Specifically, it showed …