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Full-Text Articles in Life Sciences
Characterization Of Pro-Inflammatory And Anti-Inflammatory Microglia In The Anterior Cingulate Cortex In Autism Spectrum Disorder, Aubrey N. Sciara
Characterization Of Pro-Inflammatory And Anti-Inflammatory Microglia In The Anterior Cingulate Cortex In Autism Spectrum Disorder, Aubrey N. Sciara
Electronic Theses and Dissertations
Autism spectrum disorder (ASD) is associated with functional abnormalities of the anterior cingulate cortex (ACC), a brain area that mediates social behavior. Given evidence of a role of inflammation in ASD, markers of pro-inflammatory and anti-inflammatory microglia were studied using postmortem ACC tissues from ASD and age-matched typically developed control donors. Gene expression levels of pro-inflammatory (CD68, HLA-DRA, IL1B, NOS2, PTGS2) and anti-inflammatory (ARG1, IGF1, MRC1, PPARG) microglial genes were measured using quantitative real-time PCR. Additionally, brain sections were immunohistochemically stained for a microglial marker. Expression levels of IGF1 were modestly higher, while the expression of …
The Neuroprotective And Therapeutic Effects Of Anthocyanins And Their Metabolites In Vitro And In A Mouse Model Of Amyotrophic Lateral Sclerosis, Aimee Nicole Winter
The Neuroprotective And Therapeutic Effects Of Anthocyanins And Their Metabolites In Vitro And In A Mouse Model Of Amyotrophic Lateral Sclerosis, Aimee Nicole Winter
Electronic Theses and Dissertations
Anthocyanins, a unique class of flavonoid compounds, have recently come to the forefront of investigative research aimed at evaluating the potential applications of natural products to human health. Evidence demonstrating the beneficial effects of anthocyanin consumption has been reported for a myriad of conditions including cancer, cardiovascular disease, and lately, neurodegenerative disease. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterized by the death of specific neuronal populations within the brain and spinal cord, leading to cognitive and/or motor impairment. While the etiology of many of these diseases is largely unknown, several factors have …