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Developmental Cis-Regulatory Analysis Of The Cyclin D Gene In The Sea Urchin Strongylocentrotus Purpuratus, Christopher Michael Mccarty
Developmental Cis-Regulatory Analysis Of The Cyclin D Gene In The Sea Urchin Strongylocentrotus Purpuratus, Christopher Michael Mccarty
Electronic Theses and Dissertations
Proper execution of animal development requires that it be integrated with cell division. In part, this is made possible due to cell cycle regulatory genes becoming dependent upon developmental signaling pathways that regulate their transcription. Cyclin D genes are important bridges linking the regulation of the cell cycle to development because these genes regulate the cell cycle, growth and differentiation in response to intercellular signaling. In this dissertation, a cis-regulatory analysis of a cyclin D gene, Sp-CycD, in the sea urchin, Strongylocentrotus purpuratus, is presented. While the promoters of vertebrate cyclin D genes have been analyzed, the cis-regulatory sequences across …
Role Of Cardiac Catecholamines In Embryos And Adults Under Stress, Candice Baker
Role Of Cardiac Catecholamines In Embryos And Adults Under Stress, Candice Baker
Electronic Theses and Dissertations
Cardiovascular disease is responsible for the loss of one life every 38 seconds and accounts for 26.6 percent of all infants that die of congenital birth defects. Adrenergic hormones are critically important regulators of cardiovascular physiology in embryos and adults. They are key mediators of stress responses and have profound stimulatory effects on cardiovascular function, and dysregulation of adrenergic function has been associated with many adverse cardiac conditions, including congenital malformations, arrhythmias, ischemic heart disease, heart failure, and sudden cardiac death. Despite intensive study, the specific roles these hormones play in the developing heart is not well-understood. Further, there is …