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Full-Text Articles in Life Sciences
Trained Immunity Enhances The Immune Response And Maintains Microbiome Diversity In Aging And Sepsis, P. Spencer Gill
Trained Immunity Enhances The Immune Response And Maintains Microbiome Diversity In Aging And Sepsis, P. Spencer Gill
Electronic Theses and Dissertations
The global population is rapidly aging. It is estimated that over the next thirty years, the number of individuals >60 years of age will increase by over a billion, and the number of individuals over age 80 may increase by 300 million. As humans age, our immune system becomes progressively weaker through a process called immune senescence. This age-related decrease in immune function increases susceptibility to infection and chronic diseases. Sepsis is a leading cause of death worldwide. Over the past two decades, there has been an increased incidence of sepsis which is due, in part, to our aging population …
Allowing The Experiences Of Older Adults To Be Heard: Interpreting Senior Centre Accessibility, Fallon Mitchell
Allowing The Experiences Of Older Adults To Be Heard: Interpreting Senior Centre Accessibility, Fallon Mitchell
Electronic Theses and Dissertations
Senior centres aim to support and improve the health of older adults by offering a wide variety ofservices and activities tailored to their needs, yet there is little known about accessibility of senior centres. Inaccessible environments can negatively impact participation and health potentially leading to increased sedentary behaviour and morbidity. This study explores the accessibility experiences of older adults through a case study of a senior centre in Southwestern Ontario. This study utilizes a hermeneutic phenomenological approach to ascertain a deeper understanding of the participants’ lived experiences. Six older adult members (m = 2, f = 4; Mage = 72 …
The Role Of Vps54 In Drosophila Melanogaster Neuronal Development And Age Progressive Neurodegeneration, Emily Wilkinson
The Role Of Vps54 In Drosophila Melanogaster Neuronal Development And Age Progressive Neurodegeneration, Emily Wilkinson
Electronic Theses and Dissertations
Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN). The “wobbler” mouse is the phenotypic result of a destabilizing point mutation in Vps54. This mutation causes neurodegeneration and is subsequently used as a model for human motor neuron disease. Presently, it is unclear how disruption of GARP complex function leads to motor neuron degeneration. To better understand the role of Vps54 in motor neuron development, function, and age-related neurodegeneration, we disrupted expression of the Vps54 ortholog in Drosophila and examined the impact on larval neuromuscular junction …