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Full-Text Articles in Life Sciences
The Effects Of Cucurbitacin B And Silmitasertib On Metastasis And Itga6 Using The Zebrafish Tumor-Xenograft, Alexandra Griffis
The Effects Of Cucurbitacin B And Silmitasertib On Metastasis And Itga6 Using The Zebrafish Tumor-Xenograft, Alexandra Griffis
Electronic Theses and Dissertations
Ninety percent of cancer deaths are resultant from the metastasis of cancer cells. When cancer cells translocate through blood vessels or the lymphatic system, they may form tumors outside of their primary site. The processes of metastasis can begin quickly; after onset, metastasis is unforgiving, as it does not participate with the body’s physiological systems in an orderly way. In the past, our lab produced results indicating that a cell adhesion molecule, Integrin Alpha-6, may contribute to cancer cells' ability to metastasize. Integrins mediate interactions between the cell and the Extracellular Matrix (ECM), regulating cell attachment and cell migration. With …
Neuromuscular Development And Phenotypic Variation In Zebrafish Models Of Dystroglycanopathy, Erin Bailey
Neuromuscular Development And Phenotypic Variation In Zebrafish Models Of Dystroglycanopathy, Erin Bailey
Electronic Theses and Dissertations
Skeletal muscle is highly conserved among vertebrates and is essential for strength and locomotion. This tissue becomes integrated with the skeletal system via tendons at the myotendinous junction and with the nervous system at the neuromuscular junction. Both of these specialized junctions are rich in extracellular matrix, a protein scaffold that occupies the extracellular space of cells. Skeletal muscle is also highly plastic and can grow in size (hypertrophy) or lose mass (atrophy) in response to genetic or environmental cues. Muscle atrophy is found in individuals battling a number of neuromuscular conditions, including muscular dystrophy. Muscular dystrophies are a suite …
Evaluating The Effects Of Antibody-Conjugated Multi-Walled Carbon Nanotubes In Combination With Microwave Irradiation, Amy Chall
Electronic Theses and Dissertations
Cancer remains one of the largest public health concerns of our day, particularly in developed countries where technological advances have allowed populations to live well into their eighth decade. In America, those in their 80’s have a 1 in 2 chance of developing cancer in their lifetime. Prostate cancer, specifically is the second leading cause of cancer deaths in males. Traditional cancer therapies cause high levels of toxicity to the patient due to mechanisms of action that often attack cancer cells and healthy cells alike. The holy grail of cancer research is to find a treatment that targets the cancer …
Effect Of Arsenic Exposure On Early Eye Development In Zebrafish (Danio Rerio), Remy S. Babich
Effect Of Arsenic Exposure On Early Eye Development In Zebrafish (Danio Rerio), Remy S. Babich
Electronic Theses and Dissertations
Arsenic is a metalloid that contaminates drinking water supplies worldwide. Due to concerns for human health, the World Health Organization (WHO) and the U.S. Environmental Protection Agency (EPA) have established a safe level in drinking water of ≤ 10 ppb. Arsenic has been shown to have carcinogenic effects in humans at high and low doses. Chronic exposure may result in dermal conditions such as hyperkeratosis and hyperpigmentation. Recently, arsenic exposure has also been linked to lower IQ values in children. The effect of arsenic on neurogenesis, specifically eye development, has not been widely explored. This study aimed to examine the …
Myosin 10 Is Required For Spinal Motor Axon Growth And Guidance In Zebrafish Embryos, Crystal Ivey
Myosin 10 Is Required For Spinal Motor Axon Growth And Guidance In Zebrafish Embryos, Crystal Ivey
Electronic Theses and Dissertations
Neurodevelopmental disorders are disabilities caused by malfunctioning mechanisms within the developing nervous tissue. These abnormalities often result in conditions such as autism spectrum disorders, Attention Deficient Hyperactivity Disorder (ADHD), motor dysfunctions, learning disabilities and mental retardation. Recent surveys indicate that there will be a 12% increase of children in the United States alone who are affected by neurodevelopmental disorders. Thus, it is important to understand both the normal and abnormal mechanisms of neural development. Neural development involves specification of new neurons and formation of neural circuits that connect the nervous system to every organ of the developing embryo. Neural circuits …
Myosinx Is Required For Craniofacial Development In Danio Rerio, Cole Yancey
Myosinx Is Required For Craniofacial Development In Danio Rerio, Cole Yancey
Electronic Theses and Dissertations
Craniofacial development is the process of laying early cartilage and bone patterns in the anterior region of the embryo, which ultimately results in shaping the structure of the face and head of an organism. Craniofacial abnormalities in humans, such as cleft lip and palate, are among the most common of all birth defects. Therefore, investigating the molecular mechanisms involved in craniofacial development will help us understand both evolutionary processes and genetic diseases. Craniofacial cartilage and bone structures are almost entirely derived from neural crest cells. Neural crest are a pluripotent migratory stream of cells that originate from the early developing …