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Full-Text Articles in Life Sciences
Neuromuscular Development And Phenotypic Variation In Zebrafish Models Of Dystroglycanopathy, Erin Bailey
Neuromuscular Development And Phenotypic Variation In Zebrafish Models Of Dystroglycanopathy, Erin Bailey
Electronic Theses and Dissertations
Skeletal muscle is highly conserved among vertebrates and is essential for strength and locomotion. This tissue becomes integrated with the skeletal system via tendons at the myotendinous junction and with the nervous system at the neuromuscular junction. Both of these specialized junctions are rich in extracellular matrix, a protein scaffold that occupies the extracellular space of cells. Skeletal muscle is also highly plastic and can grow in size (hypertrophy) or lose mass (atrophy) in response to genetic or environmental cues. Muscle atrophy is found in individuals battling a number of neuromuscular conditions, including muscular dystrophy. Muscular dystrophies are a suite …
Muscle Degeneration In A Zebrafish Model Of Lysosomal Related Myopathy, Elizabeth Coffey
Muscle Degeneration In A Zebrafish Model Of Lysosomal Related Myopathy, Elizabeth Coffey
Electronic Theses and Dissertations
Muscle development and homeostasis are critical for normal muscle function. A key aspect of muscle physiology during development, growth and homeostasis is modulation of protein turnover. Protein turnover is the balance between synthesis and degradation of muscle proteins. The rate of protein degradation is the major factor underlying overall muscle growth during development. Protein degradation mainly takes place in the lysosome. The efficiency of lysosomal protein degradation depends upon lysosomal pH, which is generated and maintained by proton pumps. Despite the importance of protein degradation in muscle growth during development, the impact of dysregulated lysosomal pH on muscle development, growth, …