Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Arthrogryposis (1)
- Breast cancer (1)
- C. elegans (1)
- DEAD-box helicase (1)
- Dense tissue (1)
-
- Early detection (1)
- Endothelial cells (1)
- GLH-1 (1)
- Germ Granule (1)
- Germline Stem Cell (1)
- Image-based risk assessment (1)
- Interleukin-17 receptor D (IL17RD) (1)
- Interleukin-17A (1)
- Muscle development (1)
- Muscle disease (1)
- Myeloid cells (1)
- PQN-75 (1)
- Sarcomere (1)
- Sarcomere organization (1)
- Signal transduction (1)
- Skeletal development (1)
- Visualization tool (1)
Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Exploring The Impact Of Pqn-75 And Glh-1/Vasa On Germline Development, Maintenance, And Gsc Reprogramming Using Caenorhabditis Elegans As A Model, Jesse D. Rochester
Exploring The Impact Of Pqn-75 And Glh-1/Vasa On Germline Development, Maintenance, And Gsc Reprogramming Using Caenorhabditis Elegans As A Model, Jesse D. Rochester
Electronic Theses and Dissertations
This thesis combines research on PQN-75 expression, functional motifs of GLH-1/Vasa, and germ granule components in Caenorhabditis elegans to provide a comprehensive understanding of germline development, maintenance, and reprogramming, while also examining the role of pharyngeal gland cells in stress resistance and thermotolerance. In C. elegans, pharyngeal gland cells secrete mucin-like proteins, such as PQN-75, with similarities to human PRB2. The expression of PQN-75 in gland cells confers stress resistance and thermotolerance but does not affect fertility, instead it plays a role in the organism's ability to adapt to varying environmental conditions. While, GLH-1/Vasa, an ATP-dependent DEAD-box helicase, plays …
A Quantitative Visualization Tool For The Assessment Of Mammographic Risky Dense Tissue Types, Margaret R. Mccarthy
A Quantitative Visualization Tool For The Assessment Of Mammographic Risky Dense Tissue Types, Margaret R. Mccarthy
Electronic Theses and Dissertations
Breast cancer is the second most occurring cancer type and is ranked fifth in terms of mortality. X-ray mammography is the most common methodology of breast imaging and can show radiographic signs of cancer, such as masses and calcifcations. From these mammograms, radiologists can also assess breast density, which is a known cancer risk factor. However, since not all dense tissue is cancer-prone, we hypothesize that dense tissue can be segregated into healthy vs. risky subtypes. We propose that risky dense tissue is associated with tissue microenvironment disorganization, which can be quantified via a computational characterization of the whole breast …
Muscle Defects Lead To Skeletal Deformities In A Zebrafish Model Of Distal Arthrogryposis, Emily A. Tomak
Muscle Defects Lead To Skeletal Deformities In A Zebrafish Model Of Distal Arthrogryposis, Emily A. Tomak
Electronic Theses and Dissertations
Distal Arthrogryposis Type 1 (DA1) involves mild muscle weakness and limb skeletal abnormalities thought to be caused by paralysis in utero. Why the limbs are particularly affected in DA1 and the degree of paralysis that leads to these skeletal deformities in utero remains unclear. Several muscle genes are known to cause DA1, including MYLPF (myosin light chain phosphorylatable), which encodes a myosin light chain protein that binds close to the force-generating head of myosin heavy chains. The zebrafish mylpfa-/- mutant displays a phenotype consistent with DA1, including impaired myosin activity, reduced muscle force overall, and complete fin paralysis. I …
Endothelial Interleukin-17 Receptor D (Il17rd) Promotes Western Diet-Induced Aortic Myeloid Cell Infiltration, Shivangi Pande
Endothelial Interleukin-17 Receptor D (Il17rd) Promotes Western Diet-Induced Aortic Myeloid Cell Infiltration, Shivangi Pande
Electronic Theses and Dissertations
The Interleukin-17 (IL17) family is a group of cytokines implicated in the etiology of several inflammatory diseases. Interleukin-17 receptor D (IL17RD), also known as Sef (similar expression to fibroblast growth factor), belonging to the family of IL17 receptors, has been shown to modulate IL17A-associated inflammatory phenotypes. The objective of this study was to test the hypothesis that IL17RD promotes endothelial cell activation and consequent monocyte adhesion. We utilized primary human aortic endothelial cells and demonstrated that RNAi targeting of IL17RD suppressed transcript levels by 83% compared to non-targeted controls. Further, RNAi knockdown of IL17RD decreased the adhesion of THP-1 cells …