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Full-Text Articles in Life Sciences
Bone Morphogenetic Proteins Modulate Mast Cell Responses During Inflammation, Jane S. Woodrow
Bone Morphogenetic Proteins Modulate Mast Cell Responses During Inflammation, Jane S. Woodrow
Doctoral Dissertations
Chronic inflammatory conditions can lead to detrimental health conditions that become difficult to manage and treat. Ultimately treatment requires modulation of the critical cell types involved in pathology in order to achieve homeostasis. Mast cells, a type of innate immune cell located at areas of high antigen load, are commonly thought of as primarily pro-inflammatory, but are becoming increasingly recognized in other roles, such as wound healing, anti-inflammatory actions, and homeostatic functions. In this study we investigate the role of mast cell subtypes and inflammatory mechanisms via in vitro assays using mouse and human mast cells, as well as relate …
Calcium And Leucine Modulation Of Airway Inflammation, Patricia Louise Brown
Calcium And Leucine Modulation Of Airway Inflammation, Patricia Louise Brown
Doctoral Dissertations
Over the past several decades the prevalence of obesity and asthma have increased in a parallel fashion. Recent studies reported a positive relationship between the two disorders that may in fact be causal. Although the link between obesity and asthma has become widely recognized, the underlying pathophysiological connection is not elucidated. Increased markers of inflammatory and oxidative stress are present in obesity and asthma suggesting the link is immunological. The systemic inflammation observed in obesity may potentially initiate adverse affects in the airways. Previous studies have shown that consumption of dairy foods (rich in calcium and leucine) suppress 1,25-dihydroxycholecalciferol (calcitriol) …