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Full-Text Articles in Life Sciences

Laser-Induced Breakdown Spectroscopy (Libs): A Potential Quality Tool For Infant Formula Manufacture, Xavier Cama Moncunill Sep 2019

Laser-Induced Breakdown Spectroscopy (Libs): A Potential Quality Tool For Infant Formula Manufacture, Xavier Cama Moncunill

Doctoral

Breast milk is considered the ideal food for infants. However, breastfeeding is at times supplemented or replaced with suitable alternatives. Infant formula (IF) is an industrially produced food intended as a breast milk substitute, which needs to satisfy, by itself, all nutritional requirements of infants. For this reason, it is of critical importance that IF provides the adequate amounts of nutrients including carbohydrates, fats, proteins, minerals and vitamins. Laser-induced breakdown spectroscopy (LIBS) is a promising emission spectroscopic technique for elemental analysis, which can provide real-time measurements with little to no sample preparation. Hence, the main goal of this thesis was …


Atmospheric Cold Plasma Interactions With Microbiological Risks In Fresh Food Processing, Apurva Patange Jan 2019

Atmospheric Cold Plasma Interactions With Microbiological Risks In Fresh Food Processing, Apurva Patange

Doctoral

Atmospheric cold plasma (ACP) is a novel emerging non-thermal technology that has attracted attention as a decontamination tool in several industrial, food and healthcare sectors. This study investigated the anti-microbial efficacy of ACP against microbiological risks associated with fresh foods. Treatment was performed using in-package ‘dry’ ACP technology and plasma functionalised liquid to decontaminate microorganisms, exploring the responses to real and challenging microbiological risks pertinent to both fresh foods themselves as well as the effluents generated from food processing industry. A range of critical control process parameters were investigated with respect to key pathogenic and spoilage microorganisms commonly implicated in …


Characterisation Of Cholesterolcontaining Microparticles In Autoimmunity, Shuai Shuai Hu Jan 2019

Characterisation Of Cholesterolcontaining Microparticles In Autoimmunity, Shuai Shuai Hu

Doctoral

In recent years, it has become apparent that sub-micron scale remnants of cells, called microparticles (MPs), are present in human circulation. MPs contain DNA, RNA, protein and lipids (such as cholesterol). Increased numbers of MPs are observed in autoimmune conditions such as Systemic Lupus Erythematosus (SLE) and Rheumatoid Arthritis (RA). This work aims to address the deficiency in the literature concerning MP cholesterol (MPC) by establishing reference values for MPC in a representative healthy population group, and by investigating the potential of MP cholesterol as a biomarker in autoimmunity.


Screening Of Human Serum/Plasma Using Vibrational Spectroscopy For Early Disease Diagnostics And Therapeutic Drug Monitoring, Drishya Rajan Parachalil [Thesis] Jan 2019

Screening Of Human Serum/Plasma Using Vibrational Spectroscopy For Early Disease Diagnostics And Therapeutic Drug Monitoring, Drishya Rajan Parachalil [Thesis]

Doctoral

Analysis of analytes present in the blood stream can potentially deliver crucial information on patient health and indicate the presence of numerous pathologies. Existing clinical techniques for this analysis can, however, be costly and time-consuming. The potential of Raman spectroscopic analysis of human plasma and/or serum for diagnostic purposes has been widely investigated and, increasingly, its feasibility for clinical translation has been explored. However, as the concentration of many analytes in plasma/serum is relatively low, to date such analysis has commonly been performed on air-dried drops deposited on substrates, leading to inhomogeneity and inconsistencies. This study explores the potential of …


Development And Diagnostics Of Novel Non-Thermal Plasmatreatment Systems, Laurence Scally Jan 2019

Development And Diagnostics Of Novel Non-Thermal Plasmatreatment Systems, Laurence Scally

Doctoral

Non-thermal plasma (NTP) has been a point of interest in many areas over the last few decades. Much research has been,and continues to beundertaken,to understand the fundamentals of plasma discharges. This is such a broad topic due to the very nature and variable dependencies that set the conditions for plasma discharge to occur. This can come in the form of electrode geometry and spacing, dielectric barrier thickness, humidity of environment, material selection for electrodes and dielectric barriers, the power supply used, and the operating gas(es) used. A lot of these influencing factors can be set and kept constant, but still …