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Investigations Of Factors Affecting The Transcriptional Regulation Of Herpes Simplex Virus Type 1 Βγ (Leaky-Late) Genes, Rosemary Ann Lown
Investigations Of Factors Affecting The Transcriptional Regulation Of Herpes Simplex Virus Type 1 Βγ (Leaky-Late) Genes, Rosemary Ann Lown
Dissertations and Theses
Herpes simplex virus type 1 (HSV-1) is a virus commonly causing cold sores in humans, however, virulent infections are known to produce debilitating encephalitis and death. HSV-1 transcription is carried out by the host cell RNA polymerase II in a tightly regulated temporal cascade. The first genes transcribed, the a genes, are activated in the absence of viral DNA synthesis. Transcription of the other temporal classes, the β, βγ, and γ genes is dependent upon the protein products of the a genes for activation. The purpose of this study was to investigate the factors that contribute to this rigid regulation …