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Elucidating The Role Of The Msaabcr Operon In Persister Cells Formation And Stress Response In Staphylococcus Aureus, Shanti Pandey
Elucidating The Role Of The Msaabcr Operon In Persister Cells Formation And Stress Response In Staphylococcus Aureus, Shanti Pandey
Dissertations
Staphylococcus aureus is a major human pathogen that causes lethal systemic conditions such as infective endocarditis, osteomyelitis, sepsis and pneumonia. Chronic in nature, these diseases are often refractory to the antibiotic treatment. Such recalcitrance is mainly caused due to the presence of persister cells, which are a bacterial subpopulation that exhibits extreme, yet transient antibiotic tolerance accompanied by a transient halt in the growth. However, upon cessation of antibiotic treatment, resumption in growth of persister cells causes recurrence of infections and treatment failure, displaying tremendous clinical significance. In this study, we show the involvement of the msaABCR operon in persister …
Investigating The Roles Of Lipids In Staphylococcus Aureus Infection, Xi Chen
Investigating The Roles Of Lipids In Staphylococcus Aureus Infection, Xi Chen
Dissertations
The Gram-positive bacterium Staphylococcus aureus is a major threat to public health and causes a multitude of infections, ranging from mild skin and soft infection, to more severe diseases including sepsis, osteomyelitis and infective endocarditis. As a successful pathogen, S. aureus employs various mechanisms to invade host tissues, evade immune responses, and survive in the host environment. One critical adaptive trait of S. aureus that promotes virulence and survival is the ability to maintain membrane homeostasis via flexible modifications to its lipid composition in response to the surrounding lipid environment. Phospholipids are the major component of the bacterial membrane and …