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Whole Blueberry Protects Pancreatic Beta-Cells In Diet-Induced Obese Mouse, Weixiang Liu, Yiping Mao, Jacob Schoenborn, Zhihong Wang, Guiliang Tang, Xiaoqing Tang
Whole Blueberry Protects Pancreatic Beta-Cells In Diet-Induced Obese Mouse, Weixiang Liu, Yiping Mao, Jacob Schoenborn, Zhihong Wang, Guiliang Tang, Xiaoqing Tang
Department of Biological Sciences Publications
Background
Blueberry is rich in bioactive substances and possesses powerful antioxidant potential, which can protect against oxidant-induced and inflammatory cell damage and cytotoxicity. The aim of this study was to determine how blueberry affects glucose metabolism and pancreatic β-cell proliferation in high fat diet (HFD)-induced obese mice.
Methods
Wild type male mice at age of 4 weeks received two different kinds of diets: high-fat diet (HFD) containing 60% fat or modified HFD supplemented with 4% (wt:wt) freeze-dried whole blueberry powder (HFD + B) for 14 weeks. A separate experiment was performed in mice fed with low-fat diet (LFD) containing 10% …