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Full-Text Articles in Life Sciences
The Balance Of Proangiogenic And Antiangiogenic Vegfa Isoforms Regulate Follicle Development, Renee M. Mcfee, Timonthy G. Clopton, Andrea S. Cupp
The Balance Of Proangiogenic And Antiangiogenic Vegfa Isoforms Regulate Follicle Development, Renee M. Mcfee, Timonthy G. Clopton, Andrea S. Cupp
Department of Animal Science: Faculty Publications
Vascular endothelial growth factor A (VEGFA) has been extensively studied because of its role in follicular development and is a principal angiogenic factor essential for angiogenesis. Since vascularization of the theca layer increases as follicles progress in size through preantral and antral stages, VEGFA might influence follicle growth via the regulation of angiogenesis. However, VEGFA might also influence follicular development through nonangiogenicmechanisms, since its expression has been localized in nonvascular follicles and cells. Alternative mRNA splicing of eight exons from the VEGFA gene results in the formation of various VEGFA isoforms. Each isoform has unique properties and is identified by …