Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Novel Phenol Soluble Modulin Derivatives In Community-Associated Methicillin- Resistant Staphylococcus Aureus Identified Through Imaging Mass Spectrometry., D. Gonzalez, Cheryl Okumura, A. Hollands, R. Kersten, K. Akong-Moore, M. Pence, C. Malone, J. Derieux, B. Moore, A. Horswill, J. Dixon, P. Dorrestein, V. Nizet
Novel Phenol Soluble Modulin Derivatives In Community-Associated Methicillin- Resistant Staphylococcus Aureus Identified Through Imaging Mass Spectrometry., D. Gonzalez, Cheryl Okumura, A. Hollands, R. Kersten, K. Akong-Moore, M. Pence, C. Malone, J. Derieux, B. Moore, A. Horswill, J. Dixon, P. Dorrestein, V. Nizet
Cheryl Okumura
Staphylococcus aureus causes a wide range of human disease ranging from localized skin and soft tissue infections to potentially lethal systemic infections. S. aureus has the biosynthetic ability to generate numerous virulence factors that assist in circumventing the innate immune system during disease pathogenesis. Recent studies have uncovered a set of extracellular peptides produced by community-associated methicillin-resistant S. aureus (CA-MRSA) with homology to the phenol-soluble modulins (PSMs) from Staphylococcus epidermidis. CA-MRSA PSMs contribute to skin infection and recruit and lyse neutrophils, and truncated versions of these peptides possess antimicrobial activity. In this study, novel CA-MRSA PSM derivatives were discovered by …