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A Role For Nima In The Nuclear Localization Of Cyclin B In Aspergillus Nidulans, L. Wu, S. A. Osmani, Peter M. Mirabito
A Role For Nima In The Nuclear Localization Of Cyclin B In Aspergillus Nidulans, L. Wu, S. A. Osmani, Peter M. Mirabito
Biology Faculty Publications
NIMA promotes entry into mitosis in late G2 by some mechanism that is after activation of the Aspergillus nidulans G2 cyclin-dependent kinase, NIMXCDC2/NIMECyclin B. Here we present two independent lines of evidence which indicate that this mechanism involves control of NIMXCDC2/NIMECyclin B localization. First, we found that NIMECyclin B localized to the nucleus and the nucleus-associated organelle, the spindle pole body, in a NIMA-dependent manner. Analysis of cells from asynchronous cultures, synchronous cultures, and cultures arrested in S or G2 showed that NIMECyclin B was predominantly nuclear during interphase, with maximal …