Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
The Vertebrate Tlr Supergene Family Evolved Dynamically By Gene Gain/Loss And Positive Selection Revealing A Host–Pathogen Arms Race In Birds, Imran Khan, Emanuel Maldonado, Liliana Silva, Daniela Almeida, Warren E. Johnson, Stephen James O'Brien, Guojie Zhang, Erich D. Jarvis, M. Thomas Gilbert, Agostinho Antunes
The Vertebrate Tlr Supergene Family Evolved Dynamically By Gene Gain/Loss And Positive Selection Revealing A Host–Pathogen Arms Race In Birds, Imran Khan, Emanuel Maldonado, Liliana Silva, Daniela Almeida, Warren E. Johnson, Stephen James O'Brien, Guojie Zhang, Erich D. Jarvis, M. Thomas Gilbert, Agostinho Antunes
Biology Faculty Articles
The vertebrate toll-like receptor (TLRs) supergene family is a first-line immune defense against viral and non-viral pathogens. Here, comparative evolutionary-genomics of 79 vertebrate species (8 mammals, 48 birds, 11 reptiles, 1 amphibian, and 11 fishes) revealed differential gain/loss of 26 TLRs, including 6 (TLR3, TLR7, TLR8, TLR14, TLR21, and TLR22) that originated early in vertebrate evolution before the diversification of Agnatha and Gnathostomata. Subsequent dynamic gene gain/loss led to lineage-specific diversification with TLR repertoires ranging from 8 subfamilies in birds to 20 in fishes. Lineage-specific loss of TLR8-9 and TLR13 in birds and gains of TLR6 and TLR10-12 in mammals …