Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
Molecular And Cellular Mechanisms Of Aging In Hematopoietic Stem Cells And Their Niches, Lei Zhang, Ryan Mack, Peter W. Breslin, Jiwang Zhang
Molecular And Cellular Mechanisms Of Aging In Hematopoietic Stem Cells And Their Niches, Lei Zhang, Ryan Mack, Peter W. Breslin, Jiwang Zhang
Biology: Faculty Publications and Other Works
Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the development of medications that could improve the quality life for the elderly and to treat and possibly prevent aging-related hematopoietic diseases. Here, we review the most recent advances in research into HSC aging and discuss the role of HSC-intrinsic events, as well as those that relate to the aging bone marrow niche microenvironment in the overall processes of …