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Biological Sciences Faculty Research and Publications

1997

Muscle atrophy

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Effect Of Intermittent Weight Bearing On Soleus Fiber Force-Velocity-Power And Force-Pca Relationships, J. J. Bangart, Jeffrey J. Widrick, Robert H. Fitts Jun 1997

Effect Of Intermittent Weight Bearing On Soleus Fiber Force-Velocity-Power And Force-Pca Relationships, J. J. Bangart, Jeffrey J. Widrick, Robert H. Fitts

Biological Sciences Faculty Research and Publications

Rat permeabilized type I soleus fibers displayed a 33% reduction in peak power output and a 36% increase in the free Ca2+ concentration required for one-half maximal activation after 14 days of hindlimb non-weight bearing (NWB). We examined the effectiveness of intermittent weight bearing (IWB; consisting of four 10-min periods of weight bearing/day) as a countermeasure to these functional changes. At peak power output, type I fibers from NWB animals produced 54% less force and shortened at a 56% greater velocity than did type I fibers from control weight-bearing animals while type I fibers from the IWB rats produced …


Peak Force And Maximal Shortening Velocity Of Soleus Fibers After Non-Weight-Bearing And Resistance Exercise, Jeffrey J. Widrick, Robert H. Fitts Jan 1997

Peak Force And Maximal Shortening Velocity Of Soleus Fibers After Non-Weight-Bearing And Resistance Exercise, Jeffrey J. Widrick, Robert H. Fitts

Biological Sciences Faculty Research and Publications

Widrick, Jeffrey J., and Robert H. Fitts. Peak force and maximal shortening velocity of soleus fibers after non-weight-bearing and resistance exercise. J. Appl. Physiol. 82(1): 189–195, 1997.—This study examined the effectiveness of resistance exercise as a countermeasure to non-weight-bearing-induced alterations in the absolute peak force, normalized peak force (force/fiber cross-sectional area), peak stiffness, and maximal shortening velocity (V o) of single permeabilized type I soleus muscle fibers. Adult rats were subjected to one of the following treatments: normal weight bearing (WB), non-weight bearing (NWB), or NWB with exercise treatments (NWB+Ex). The hindlimbs of the NWB and NWB+Ex rats were …