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Full-Text Articles in Life Sciences
Genome-Wide Analysis Of Methylome In The Mouse Brain Using Long-Read Sequencing Technology, Zachary Even, He Huang, Ramkumar Mathur, Xusheng Wang
Genome-Wide Analysis Of Methylome In The Mouse Brain Using Long-Read Sequencing Technology, Zachary Even, He Huang, Ramkumar Mathur, Xusheng Wang
Arts & Sciences Undergraduate Showcase
DNA methylation is an epigenetic modification that transfers a methyl group onto the C-5 position of the cytosine to form 5-methylcytosine. DNA methylation regulates gene expression by recruiting proteins involved in gene repression or by inhibiting the binding of transcription factor(s) to DNA, especially in regulation of Allele Specific Expression (ASE). In this study, we used Oxford Nanopore long-read sequencing technology to profile methylome in the two inbred mouse strains, C57BL/6J (B6) and DBA/2J (D2). Compared with bisulfite conversion followed by Illumina Sequencing, long-read sequencing technology allows us to achieve much longer read length of 4,653.675 base pairs on average …
Environmental Impacts Of Contact Lens Waste, Abigail Wilhelmi
Environmental Impacts Of Contact Lens Waste, Abigail Wilhelmi
Arts & Sciences Undergraduate Showcase
Contact lenses have been used for decades to correct vision, and over 150 million people use contact lenses today. The materials used to make contact lenses have evolved drastically, but ultimately resulted in a specific plastic, silicone-derived hydrogel, which provides maximal comfort and clear vision, while also maintaining the eye health of the user. Contact lenses have enhanced the lives of many people, but a topic that is often left out of contact lens discussions is that of plastic waste. Single-use plastic and increased plastic pollution have recently been areas of concern and expanded research. Contact lenses are often forgotten …