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The Role Of The Fatty Acid Signaling Pathway In Dietary-Induced Obesity, Melissa N. Nelson
The Role Of The Fatty Acid Signaling Pathway In Dietary-Induced Obesity, Melissa N. Nelson
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
In recent years, dietary fat has been shown to be capable of activing taste receptor cells in the tongue. Fatty acids (FAs), which act as the chemical cue and are found in dietary fat, activate a cellular signaling pathway that results in a unique signal being sent to the brain that is then interpreted as the taste of fat. One important element in this pathway is the ion channel TrpM5. It is responsible for depolarizing the taste cells that are activated by fatty acids; depolarization is an essential step in cellular response, making TrpM5 essential in the functioning of the …