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Pharmacokinetic Assessment Of The Influence Of Dietary Fiber On The Absorption And Disposition Of Selected Model Xenobiotics As It Relates To Colon Cancer, Joseph Donald Debethizy
Pharmacokinetic Assessment Of The Influence Of Dietary Fiber On The Absorption And Disposition Of Selected Model Xenobiotics As It Relates To Colon Cancer, Joseph Donald Debethizy
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Selected drugs are being utilized as models of putative colon carcinogens in a study of the influence of major types of dietary fiber upon drug pharmacokinetics. Adult, male Wistar rats were pretreated with standardized, isocaloric hydrated gelatin diets containing no fiber or 15% (w/w) cellulose, lignin, hemicellulose (metamucil), or pectin for 30 days. An additional group was fed lab chow ad libitum as a reference control.
The pharmacokinetics of acetaminophen, FD & C Red No. 2 and mirex were examined following oral administration in three separate experiments. Among fiber types, pectin and hemicellulose (Metamucil) caused higher peak plasma concentrations of …