Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Life Sciences
The Hypercapnic Ventilatory Response And Behavior In Ca2+-Activated K+ (Bk) Channel Knock Out Mice And T-Cell Death-Associated Gene 8 (Tdag8) Receptor Knock Out Mice, Christine Annette Ratliff-Rang
The Hypercapnic Ventilatory Response And Behavior In Ca2+-Activated K+ (Bk) Channel Knock Out Mice And T-Cell Death-Associated Gene 8 (Tdag8) Receptor Knock Out Mice, Christine Annette Ratliff-Rang
Browse all Theses and Dissertations
Some acid sensing areas in the brain control the expression of breathing and anxiety/fear including the locus coeruleus (LC) (Redmond & Huang, 1979) and the nucleus tractus solitarius (NTS). It has been found that knocking out T-cell death-associated gene 8 (TDAG8), a chemosensor, attenuates CO2 induced fear phenotypes in mice. However their hypercapnic ventilatory response (HCVR) has not yet been looked at. Also, BK channels are large-conductance, calcium-activated potassium channels that are activated by increases in concentration of intracellular calcium ions. It has been found that BK KO rats have an increase in their HCVR (Patrone et al., 2014) however …