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Synaptic Contact Localization In Three Dimensional Space Using A Center Distance Algorithm, Benjamin D. Ausdenmoore
Synaptic Contact Localization In Three Dimensional Space Using A Center Distance Algorithm, Benjamin D. Ausdenmoore
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Spatial distribution of synaptic inputs on the dendritic tree of a neuron can have significant influence on neuronal function. Consequently, accurate anatomical reconstructions of neuron morphology and synaptic localization are critical when modeling and predicting physiological responses of individual neurons. Historically, generation of three-dimensional (3D) neuronal reconstructions together with comprehensive mapping of synaptic inputs has been an extensive task requiring manual identification of putative synaptic contacts directly from tissue samples or digital images. Recent developments in neuronal tracing software applications have improved the speed and accuracy of 3D reconstructions, but localization of synaptic sites through the use of pre- and/or …
Environmental Enrichment-Mediated Neuroprotection Against Traumatic Brain Injury:Role Of Brain-Derived Neurotrophic Factor, Kyle Leann Traver
Environmental Enrichment-Mediated Neuroprotection Against Traumatic Brain Injury:Role Of Brain-Derived Neurotrophic Factor, Kyle Leann Traver
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Each year there are over 1.7 million traumatic brain injuries (TBI) in the United States causing long-term health deficits and significant medical costs. This growing epidemic has led researchers to find methods for treating and preventing these injuries. Environmental Enrichment (EE) is an innovative technique shown to improve cognitive and functional outcomes following a TBI; however, the beneficial effects before injury have not been established. Brain-Derived Neurotrophic Factor (BDNF) has been determined as a neuroprotective biomolecule in TBI. This research examined these two protective components and their roles in TBI. It was hypothesized that BDNF mRNA and protein levels would …