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Modulation Of The 3'Igh Regulatory Region (3'Igh Rr), A Prospective In Vitro Screening Tool For Identifying Potential Immunotoxicants, Rebecca Anne Henseler
Modulation Of The 3'Igh Regulatory Region (3'Igh Rr), A Prospective In Vitro Screening Tool For Identifying Potential Immunotoxicants, Rebecca Anne Henseler
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The immune system is critical to human survival. However, assessing alterations of immune function by potential immunotoxicants is complicated by the diffuse nature of the immune system, which is composed of various effector cells each with differing effector functions. Current immunotoxicity testing is limited to animal studies. We have developed a model, which may provide an in vitro alternative to animal studies in identifying immunotoxicants that specifically target B cell function (i.e., alteration of immunoglobulin (Ig) or expression and antibody secretion). This model consists of a well-characterized B cell line, CH12.LX, which appears to appropriately model primary B cell function. …
Immunological And Developmental Effects Of Polybrominated Diphenyl Ethers (Pbdes) And 2,3,7,8-Tetrachloro-P-Dioxin (Tcdd) In Birds, Randy T. Stetzer
Immunological And Developmental Effects Of Polybrominated Diphenyl Ethers (Pbdes) And 2,3,7,8-Tetrachloro-P-Dioxin (Tcdd) In Birds, Randy T. Stetzer
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This thesis contains two separate and distinct research projects with a common overall theme - the study of immunotoxicity associated with the developmental exposure of young birds to halogenated chemicals posing environmental concern. These chemicals share many chemical characteristics, including environmental ubiquity and longevity, one has been studied extensively since the 1970s, and one is a relatively new environmental contaminant with few studies pertaining to toxicological affects on humans or wildlife. Specific summaries of each study begin each project chapter. The first study was entitled Developmental and Immunological Effects of a Commercial Mixture of PBDE Flame Retardants in Chicken Embryos. …