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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Semantics-Based Information Brokering: A Step Towards Realizing The Infocosm, Vipul Kashyap, Amit P. Sheth
Semantics-Based Information Brokering: A Step Towards Realizing The Infocosm, Vipul Kashyap, Amit P. Sheth
Kno.e.sis Publications
The rapid advances in computer and communication technologies, and their merger, is leading to a global information market place. It will consist of federations of very large number of information systems that will cooperate to varying extents to support the users' information needs. We propose an architecture which may facilitate meeting these needs. It consists of three main components: information providers, information brokers and information consumers. We also propose an approach to information brokering. We discuss two of it's tasks: information resource discovery, which identities relevant information sources for a given query, and query processing, which involves the generation of …
Specifying And Enforcing Intertask Dependencies, Paul Attie, Munindar Singh, Amit P. Sheth, Marek Rusinkiewicz
Specifying And Enforcing Intertask Dependencies, Paul Attie, Munindar Singh, Amit P. Sheth, Marek Rusinkiewicz
Kno.e.sis Publications
Extensions of the traditional atomic transaction model are needed to support the development of multi-system applications or workflows that access heterogeneous databases and legacy application systems. Most extended transaction models use conditions involving events or dependencies between transactions. Intertask dependencies can serve as a uniform framework for defining extended transaction models. In this paper we introduce event attributes needed to determine whether a dependency is enforceable and to properly schedule events in extended transaction models. Using these attributes and a formalization of a dependency into the temporal logic CTL, we can automatically synthesize an automaton that captures the computations that …
Simian Immunodeficiency Virus Mutants Resistant To Serum Neutralization Arise During Persistent Infection Of Rhesus Monkeys, Dawn P. Wooley, Catherine Collignon, Ronald C. Desrosiers
Simian Immunodeficiency Virus Mutants Resistant To Serum Neutralization Arise During Persistent Infection Of Rhesus Monkeys, Dawn P. Wooley, Catherine Collignon, Ronald C. Desrosiers
Neuroscience, Cell Biology & Physiology Faculty Publications
We previously described the pattern of sequence variation in gp120 following persistent infection of rhesus monkeys with the pathogenic simian immunodeficiency virus SIVmac239 molecular clone (D.P.W. Burns and R.C. Desrosiers, J. Virol. 65:1843, 1991). Sequence changes were confined largely to five variable regions (V1 to V5), four of which correspond to human immunodeficiency virus type 1 (HIV-1) gp120 variable regions. Remarkably, 182 of 186 nucleotide substitutions that were documented in these variable regions resulted in amino acid changes. This is an extremely nonrandom pattern, which suggests selective pressure driving amino acid changes in discrete variable domains. In the present study, …
A Framework For Controlling Cooperative Agents, Kuo-Chu Lee, William H. Mansfield, Amit P. Sheth
A Framework For Controlling Cooperative Agents, Kuo-Chu Lee, William H. Mansfield, Amit P. Sheth
Kno.e.sis Publications
Presents an overview of the ITX (Interacting Transaction) system, which supports complex interactions among cooperating agents in the presence of user interventions that change application objectives and system failures. The system's components and its unique fixed-point criterion for feedback control of iterative interactions are described. An example of a simplified multimedia teleconferencing application is discussed to illustrate the features of the ITX system.
So Far (Schematically) Yet So Near (Semantically), Amit P. Sheth, Vipul Kashyap
So Far (Schematically) Yet So Near (Semantically), Amit P. Sheth, Vipul Kashyap
Kno.e.sis Publications
In a multidatabase system, schematic conflicts between two objects are usually of interest only when the objects have some semantic affinity. In this paper we try to reconcile the two perspectives. We first define the concept of semantic proximity and provide a semantic taxonomy. We then enumerate and classify the schematic and data conflicts. We discuss possible semantic similarities between two objects that have various types of schematic and data conflicts. Issues of uncertain information and inconsistent information are also addressed.
On Transactional Workflows, Amit P. Sheth, Marek Rusinkiewicz
On Transactional Workflows, Amit P. Sheth, Marek Rusinkiewicz
Kno.e.sis Publications
The basic transaction model has evolved over time to incorporate more complex transactions structures and to take the advantage of semantics of higher-level operations that cannot be seen at the level of page reads and writes. Well known examples of such extended transaction models include nested and multi-level transactions. A number of relaxed transaction models have been defined in the last several years that permit a controlled relaxation of the transaction isolation and atomicity to better match the requirements of various database applications. Correctness criteria other than global serializability have also been proposed. Several examples of extended/relaxed transaction models are …