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Nutrition And Exercise Interventions During Pregnancy: How Important Is Adherence?, Taniya S. Nagpal
Nutrition And Exercise Interventions During Pregnancy: How Important Is Adherence?, Taniya S. Nagpal
Electronic Thesis and Dissertation Repository
Lifestyle interventions (nutrition and exercise) offered during pregnancy may prevent excessive gestational weight gain (EGWG) and improve pregnancy outcomes. The efficacy of previous interventions has been inconsistent as some studies ‘successfully’ achieve their health outcome goals while others have had a null effect. A common limitation reported among ‘unsuccessful’ studies is low adherence. The objective of this dissertation was to execute three independent yet interrelated studies to determine if adherence is a key factor in determining the success of a lifestyle intervention during pregnancy. Study 1 compared adherence to ‘successful’ and ‘unsuccessful’ lifestyle interventions during pregnancy using a systematic review. …
Oleic Acid Attenuates Palmitic Acid-Induced Impairments In Mouse Blastocyst Development, Maisoon Dafalla Yousif
Oleic Acid Attenuates Palmitic Acid-Induced Impairments In Mouse Blastocyst Development, Maisoon Dafalla Yousif
Electronic Thesis and Dissertation Repository
Palmitic acid (PA) and oleic acid (OA) are the most abundant saturated and monounsaturated non-esterified fatty acids, respectively, in serum. The consequences of PA and OA treatment on preimplantation mouse embryo development were investigated. It was hypothesized that OA treatment from the two-cell stage onwards would attenuate PA-induced reductions in mouse blastocyst development. PA significantly reduced development to the blastocyst stage. Transcript analysis revealed that PA increased ER stress pathway markers activating transcription factor 3 and C/EBP homologous protein transcripts, and XBP1 splicing. Co-culture of PA-treated embryos with OA prevented this PA-induced ER stress and rescued blastocyst development. Cytoplasmic lipid …