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Influence Of Sex And Age On Muscle Sympathetic Nerve Activity Of Healthy Normotensive Adults, Daniel A. Keir, Mark B. Badrov, George Tomlinson, Catherine F. Notarius, Derek S. Kimmerly, Philip J. Millar, J Kevin Shoemaker, John S. Floras
Influence Of Sex And Age On Muscle Sympathetic Nerve Activity Of Healthy Normotensive Adults, Daniel A. Keir, Mark B. Badrov, George Tomlinson, Catherine F. Notarius, Derek S. Kimmerly, Philip J. Millar, J Kevin Shoemaker, John S. Floras
Kinesiology Publications
As with blood pressure, age-related changes in muscle sympathetic nerve activity (MSNA) may differ nonlinearly between sexes. Data acquired from 398 male (age: 39±17; range: 18-78 years [mean±SD]) and 260 female (age: 37±18; range: 18-81 years) normotensive healthy nonmedicated volunteers were analyzed using linear regression models with resting MSNA burst frequency as the outcome and the predictors sex, age, MSNA, blood pressure, and body mass index modelled with natural cubic splines. Age and body mass index contributed 41% and 11%, respectively, of MSNA variance in females and 23% and 1% in males. Overall, changes in MSNA with age were sigmoidal. …