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Oncolytic Tanapoxvirus For Melanoma Therapy, Tiantian Zhang
Oncolytic Tanapoxvirus For Melanoma Therapy, Tiantian Zhang
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Oncolytic viruses (OVs), which preferentially infect cancer cells and induce host anti- tumor immune responses, have emerged as an effective melanoma therapy. Tanapoxvirus (TPV), which possesses a large genome and causes mild self-limiting disease in humans, is potentially an ideal OV candidate. The purposes of our studies are to engineer TPV into effective OVs via arming immumo-stimulatory proteins and/or manipulating the virokines, and to explore the immuno-modulatory activities of TPV.
Interleukin-2 (IL-2) plays a critical role in activating T cells, natural killer cells and macrophages in both the innate and adaptive immune systems. In our study, a recombinant TPV expressing …