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Full-Text Articles in Life Sciences
Exercise-Induced Lymphocyte Apoptosis And Relationship With Level Of Lactate In Smokers And Non-Smokers, Kyung-Shin Park, Yang Lee
Exercise-Induced Lymphocyte Apoptosis And Relationship With Level Of Lactate In Smokers And Non-Smokers, Kyung-Shin Park, Yang Lee
International Journal of Exercise Science
Purposes of this study were 1) to examine the exercise intensity where lymphocyte apoptosis index (AI) is significantly increased in smokers and non-smokers, 2) to find out whether AI is associated with level of lactate (L). METHODS: Fourteen healthy untrained smokers (≥ 1 pack year, n=7) and non-smokers (n=7) aged 18 to 26 were recruited. Each subject conducted three treadmill runs at different intensities randomly. Running distance for all three runs was equivalent to 30 minute run at 70% VO2max. AI and L were analyzed at rest (Pre), immediately after (Post), and 1 h following (1 h post) each run. …
Voluntary Wheel Running During Weight Loss Leads To Differential Changes In Monocytes, Compared To Forced Treadmill Running, Katie C. Carpenter, Kelley Strohacker, Whitney L. Breslin, Thomas W. Lowder, Brian K. Mcfarlin
Voluntary Wheel Running During Weight Loss Leads To Differential Changes In Monocytes, Compared To Forced Treadmill Running, Katie C. Carpenter, Kelley Strohacker, Whitney L. Breslin, Thomas W. Lowder, Brian K. Mcfarlin
International Journal of Exercise Science: Conference Proceedings
High-fat feeding and subsequent weight gain may contribute to innate immune dysfunction. Weight loss via calorie restriction and exercise represent one means to restore normal immune function. The purpose of the study was to examine how 8- weeks of aerobic exercise and low-fat diet affects weight gain, monocyte concentration, and monocyte cell-surface expression of TLR2, TLR4, CD80, and CD86. For 12- months, 24 male CD-1 mice underwent a pre-treatment phase, consuming either a low fat (10% fat) or high-fat (60% fat) diet ad libitum. Mice were randomly assigned to one of four groups (N=6/group): CN (low-fat sedentary), V-EX (voluntary wheel …
Exercise Prior To Pregnancy Enhances The Suppressive Function Of Tregs In Offspring In A Mouse Model Of Asthma, Hawley E. Kunz, Lydia Montes, Thomas W. Lowder
Exercise Prior To Pregnancy Enhances The Suppressive Function Of Tregs In Offspring In A Mouse Model Of Asthma, Hawley E. Kunz, Lydia Montes, Thomas W. Lowder
International Journal of Exercise Science: Conference Proceedings
Regulatory T cells (Tregs) are a specialized subset of T cells responsible for peripheral tolerance and the mediation of inappropriate immune responses, such as those seen in asthma and allergy. Our lab is interested in the role that exercise plays in Treg responses. Using a mouse model of asthma, we have shown that exercise increases both the number and suppressive function of Tregs. It has been shown that exposing nursing dams to allergens confers protection against airway hyperresponsiveness and inflammation (trademarks of asthma) in pups exposed to the same allergen. In the present study, we wanted to determine if the …
Childhood Overweight Is Associated With Increased Monocyte Concentration And Altered Subset Distribution, Whitney L. Breslin, Craig A. Johnston, Kelley Strohacker, Katie C. Carpenter, Tiffany Davidson, Jennette Palic, Brian K. Mcfarlin, John P. Foreyt
Childhood Overweight Is Associated With Increased Monocyte Concentration And Altered Subset Distribution, Whitney L. Breslin, Craig A. Johnston, Kelley Strohacker, Katie C. Carpenter, Tiffany Davidson, Jennette Palic, Brian K. Mcfarlin, John P. Foreyt
International Journal of Exercise Science: Conference Proceedings
Childhood obesity rates have nearly tripled in the last 30 years. Obesity increases risk for chronic disease. While monocytes, cells of the innate immune system that are altered with obesity, are purported to play an integral role in the development of these chronic diseases, no research has focused on early phenotypic changes in monocytes of overweight children. Two monocytes subsets exist, classic and pro-inflammatory; alterations in number and distribution may be implicated in disease development in obesity. The purpose of this study was to examine the concentration and relative distribution of monocytes among “normal weight” (N=66) and “at risk for …
Effect Of Hsv-1 Infection On The Exercise-Induced Mobilization Of T-Cell Subsets, Emily C.P. Lavoy, J. Austin Bigley, Mark R. Morrison, Guillaume Spielmann, Jerrald L. Rector, Richard J. Simpson
Effect Of Hsv-1 Infection On The Exercise-Induced Mobilization Of T-Cell Subsets, Emily C.P. Lavoy, J. Austin Bigley, Mark R. Morrison, Guillaume Spielmann, Jerrald L. Rector, Richard J. Simpson
International Journal of Exercise Science: Conference Proceedings
Acute exercise mobilizes highly-differentiated memory and senescent T-cells into the blood compartment, which could have important implications for post-exercise immune surveillance. This response differs in individuals with latent cytomegalovirus (CMV) infection (a herpesvirus), but it is unknown if other latent herpesviruses, such as herpes simplex virus type 1 (HSV-1), also influence this exercise-induced immune response. As HSV-1 infects 50% of the US population, this could have implications for many athletes. PURPOSE: To examine the effects of an acute bout of exercise on the frequency and relative proportion of naïve, memory, and senescent T-cells in the peripheral blood in HSV-1 infected …