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Characterizing Cyclin J By Identifying Conserved Protein-Protein Interactions, Phillip Jacob Selman
Characterizing Cyclin J By Identifying Conserved Protein-Protein Interactions, Phillip Jacob Selman
Wayne State University Theses
Cyclins are proteins that bind to Cyclin-dependent kinases, or Cdks, through a conserved domain called the Cyclin Box. Many Cyclins regulate the cell cycle. A few Cyclins impact cellular processes outside of the cell cycle. Also, a few Cyclins have poorly understood functions.
Cyclin J is a member of the Cyclin superfamily of proteins. Cyclin J is conserved among all metazoans, but is presently not well understood. All the research done on Cyclin J has been done in Drosophila.
Its mRNA is present in the early embryo, then disappears, only to reappear in adult females. When probing protein extracts with …
Cysteine Desulfurase And Isd11: A Drosophila Model, Rahul Ravindran Nair
Cysteine Desulfurase And Isd11: A Drosophila Model, Rahul Ravindran Nair
Wayne State University Theses
ABSTRACT
Cysteine desulfurase and Isd11: A Drosophila model
Iron-sulfur clusters are cofactors with evolutionary origins that date back to the pre-biotic world. Ever since life originated, these cofactors have intermingled with proteins to play vital roles in sustaining life. My research focuses on one such protein, the cysteine desulfurase (Nfs) that has the PLP cofactor incorporated in its active site and avails of the catalytic property of PLP to provide sulphur for Iron-sulfur cluster biogenesis and assembly in a cell. Interestingly, in a eukaryotic cell, despite the versatility of PLP, cysteine desulfurase's role as a "sulphur-extractor" is incomplete without another …