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Full-Text Articles in Life Sciences
Functional Characterization Of Threonine 49 Phosphorylation Of Cytochrome C, Antoine Khobeir
Functional Characterization Of Threonine 49 Phosphorylation Of Cytochrome C, Antoine Khobeir
Wayne State University Theses
Cytochrome c (Cytc) is a pivotal multifunctional mitochondrial protein that serves as a single electron carrier between complexes III and IV of the electron transport chain. It has important roles in both cellular respiration and apoptosis. The novel Thr49 (T49) phosphorylation of Cytc likely affects mitochondrial respiration, membrane potential, ROS production, ATP production, and apoptosis. Based on the functional characterization of previously mapped phosphorylation sites (Tyr97, Tyr48, Thr28, Ser47, Thr58) of the lab, we hypothesize that T49 phosphorylation will lead to controlled respiration, optimal intermediate mitochondrial membrane potential, lower ROS production, and inhibition of apoptosis compared to unphosphorylated Cytc. Here …
The Relationships Among Personality Traits, Food Consumption, And Anthropometrics In Healthy People, Chelsea Schwartz
The Relationships Among Personality Traits, Food Consumption, And Anthropometrics In Healthy People, Chelsea Schwartz
Wayne State University Theses
Two out of three people are obese in the United States, but Western culture isn’t the only population suffering from obesity and comorbidities. Many factors contribute to this global epidemic and more recently various research suggests that personality traits can be used to predict eating behaviors. This study investigated the Big Five personality trait’s influence on food consumption to determine what traits contribute to healthy eating and what traits are susceptible to overeating and therefore, poor health consequences. The Big Five personality traits, anthropometric measures, and diet logs were used to assess 38 individuals for health-related behaviors and obesity-related risk …
Novel Role Of Endoplasmic Reticulum-Associated Degradation In The Regulation Of Ceruloplasmin, Stephen William Hippleheuser
Novel Role Of Endoplasmic Reticulum-Associated Degradation In The Regulation Of Ceruloplasmin, Stephen William Hippleheuser
Wayne State University Theses
Ceruloplasmin (Cp) is a secreted ferroxidase produced by the hepatocytes that assists in the transport of iron throughout the human body. In human aceruloplasminemia patients, due to Cp deficiency excess intracellular iron buildup leads to ailments like liver cirrhosis, neurodegeneration, and blindness. We recently found that the biogenesis of Cp in the endoplasmic reticulum (ER) is regulated by a principal ER quality-control process, ER-associated degradation (ERAD). ERAD clears misfolded ER proteins for cytosolic proteasomal degradation, with the Sel-1 suppressor of lin-12-like (Sel1L)-HMG-CoA reductase degradation 1 (Hrd1) protein complex representing the most conserved branch in mammals. Interestingly, we found that Sel1L-Hrd1 …