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Investigation Of A 16s Rna Central Domain Pseudoknot, Jenna Marie Jasinski-Bolak
Investigation Of A 16s Rna Central Domain Pseudoknot, Jenna Marie Jasinski-Bolak
Wayne State University Theses
X-ray crystallography of the prokaryotic 30S ribosomal subunit revealed a myriad of complex RNA-RNA, RNA-protein, and protein-protein interactions. Among these are several phylogenetically conserved RNA pseudoknots. Pseudoknots are structurally and functionally diverse RNA secondary structures. They are generally formed by two short complimentary sequences separated by many bases of single stranded regions or loops. These relatively simple folds are often yield complex structures that are key components of functionally important conformational changes in RNA structure. One such pseudoknot is located in the central domain of the 16S rRNA.
The central domain pseudoknot is formed by Watson-Crick base pairing between G570-C866 …