Life Sciences Commons^™

The Role Of Mitochondria In The Radiation-Induced Bystander Effect In Human Lymphoblastoid Cells, Sountharia Rajendran

Wayne State University Theses

This work evaluated the radiation-induced bystander effect in mitochondrial mutant cells and in normal cells treated with mitochondrial inhibitors. Although much research has been performed on the bystander effect, the underlying molecular mechanisms remain largely unknown. Cells without intact mitochondrial DNA have been shown to lack the bystander effect, which is an energy-dependent process. Based on these findings, cells harboring mutations in the mitochondrial genes responsible for ATP synthesis, and normal cells treated with mitochondrial inhibitors, were hypothesized to show a decreased bystander effect when compared to normal cells that were not treated with the mitochondrial inhibitors.

Radiation-induced bystander effects …

The Roles Of Rhle And Hfq In Srna-Dependent Gene Regulation, Abeykoon Jayalath Iresha Sandeepanie Rathnayake

Wayne State University Theses

THE ROLES OF RHLE AND HFQ IN SRNA-DEPENDENT GENE REGULATION

by

ABEYKOON JAYALATH IRESHA SANDEEPANIE RATHNAYAKE

DECEMBER 2010

Advisor: Dr. Andrew Feig

Major: Chemistry

Degree: Master of Science

Bacteria are adapted to live in diverse environmental conditions. Thus, they show excellent tolerance and response to extreme environmental conditions caused by low or high temperatures, high salinity, reactive oxygen species or high nutrient concentrations. sRNAs have been identified and characterized as cis-acting or trans-acting post-transcriptional regulators in diverse cellular processes including virulence and adaptation to environmental stress (11,12,14,15). Interactions of sRNAs and target mRNAs result in translational repression, translational activation or/and …

Identification Of Deletion Mutants Of Inositol Kinases And Phosphatases Hypersensitive To Valproate, W-Mudiyanselage Manoj Senaka Bandara

Wayne State University Theses

ABSTRACT

IDENTIFICATION OF DELETION MUTANTS OF INOSITOL KINASES AND PHOSPHATASES HYPERSENSITIVE TO VALPROATE

by

WELLEWATTA MUDIYANSELAGE MANOJ SENAKA BANDARA

MAY 2010

Advisor: Dr. Miriam Greenberg

Major: Biological Sciences

Degree: Master of Science

Bipolar disorder (BD) is a chronic psychiatric illness affecting at least 1% of the world population. BD is ranked as the sixth greatest cause of death or disability globally. The cause of BD is unknown. Although the anticonvulsant valproate (VPA) is widely used as a mood stabilizer to treat BD, VPA is not completely effective and causes numerous side effects. Hence, it is important to develop more effective …

Effect Of Exogenous Leptin On Thrombotic And Metabolic Profiles Of Fvb/B6 Lipodystrophic Mice, Hoda Chaouki Kadouh

Wayne State University Theses

Lipodystrophy caused by fat deficiency contributes to metabolic disease for which several treatment modalities have been implemented, with leptin therapy being the most effective to date. In addition to playing a role in energy homeostasis and metabolism, leptin was also shown to play a pro-thrombotic role in mice. This role was not examined in fatless mice, neither was thrombosis measured. The AZIP/F-1 (FVB) lipodystrophic mouse appeared to have a prolonged arterial occlusion time (p〈0.05) in a trial done in our lab, with clotting factors being normal. The present study was designed to observe the thrombotic and metabolic characteristics of fatless …