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Full-Text Articles in Life Sciences
Effect Of Basal Diet And Black Raspberry Supplementation On Gene Biomarkers Of "Leaky Gut" In Mouse Model Of Colitis-Associated Colorectal Cancer, Eliza Stewart
Fall Student Research Symposium 2021
Colorectal cancer is currently the third leading cause of cancer death in the world. The risk of developing colorectal cancer increases significantly in individuals who suffer from colitis, which is inflammation of the colon lining, seen in Irritable Bowel Disease. The term “leaky gut” is often used to describe increased intestinal permeability and is closely related to colitis. Leaky gut is associated with dysbiosis of the gut microbiota, which can occur through diet. This dysbiosis leads to pro-longed inflammation and affects genes that encode for proteins involved in the tight junctions between cells. Compromised intestinal integrity allows for translocation of …
Fecal Microbiota Transfer (Fmt) From Tumor-Bearing Mice Fed The Total Western Diet (Twd) Does Not Contribute To A Higher Tumor Burden In Mice Fed A Healthy Diet, Porter Green
Student Research Symposium
Colorectal cancer (CRC) is the third most common cause of cancer death in the United States. Diet and gut microbiome have shown to influence the development of colitis associated colorectal cancer (CAC). For this study, the goal was to determine the association between colon inflammation, diet and microbiome in the development of CAC in mice. The primary objective of this study was to determine the contribution of gut microbiota from mice donors who have previously consumed one of two basal diets: 1) the standard AIN93G diet, which is designed to promote rodent health; and 2) the total Western diet (TWD), …
Cytokine Indicators Of Inflammation In Mice Fed A Western Type Diet, Eliza Owens, Emily Mortensen
Cytokine Indicators Of Inflammation In Mice Fed A Western Type Diet, Eliza Owens, Emily Mortensen
Student Research Symposium
Colorectal cancer is currently the second leading cause of cancer-related deaths in the United States. The risk of colon cancer increases in individuals who suffer from colitis, which is inflammation of the colon lining. Colitis is common in patients with inflammatory bowel disease (IBD). The development of colorectal cancer is complex and can be associated with dysbiosis of the gut microbiota, which has been shown to be affected by diet. Disruption of the gut microbiome can lead to the overgrowth of pathogenic bacteria which can contribute to disease. Pathogenic bacteria and other bacterial byproducts that manage to cross the epithelial …
Impact Of Fecal Microbiota Transfer (Fmt) On Phenotype Of Mice Fed A Standard Diet And A Western-Style Diet Using A Colitis-Associated Colorectal Cancer Model, Abbey Horrocks
Student Research Symposium
A variety of genetic and environmental factors can affect the composition of the human gut microbiota, including a poor diet. Western diets are typically associated with dysbiosis and other adverse health outcomes that are expressed phenotypically. The primary objective of this study is to determine the contribution of gut microbiota from mice donors who have previously consumed one of two basal diets: 1) the standard AIN93G diet, which is designed to promote rodent health; and 2) the total Western diet (TWD), which promotes inflammation-associated colorectal tumorigenesis. The donors’ microbiota were transferred to a cohort of mice who were fed either …