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Use Of Recombinant Human Granulocyte Colony Stimulating Factor As An Adjunct In Antifungal Chemotherapy In Various Animal Model Systems, Lindi Farrell
Use Of Recombinant Human Granulocyte Colony Stimulating Factor As An Adjunct In Antifungal Chemotherapy In Various Animal Model Systems, Lindi Farrell
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The growing neutropenic patient population provides an ideal target for opportunistic fungal infections. Several effective antifungal drugs are toxic at high doses and contraindicated for long-term treatment. Recombinant human granulocyte colony stimulating factor (rhG-CSF) has been shown to increase neutrophilic numbers and functions, thus providing enhanced host defense. Improved efficacy by using rhG-CSF in conjunction with various antifungal agents was the primary focus of these studies. Use of rhG-CSF in a murine model of vaginal candidiasis did not reduce vaginal colony counts, or improve vaginal histophathology scores. Administration of rhG-CSF in a murine model of pulmonary aspergillosis improved survival, clinical …