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Characterization Of A Dexamethasone-Immunosuppressed C57bl/6n Mouse Model For Chronic Cryptosporidiosis, Edward G. Martin

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Cryptosporidium parvum is a coccidian protozoan that colonizes epithelial cells lining respiratory and digestive tracts of animals and humans. Cryptosporidiosis is a well-recognized zoonotic disease infecting primarily neonates and immunocompromised hosts, including human immunodeficiency virus-infected patients. Clinical disease is manifested as a chronic diarrheal illness that is self-limiting in immunocompetent hosts and prolonged and often life-threatening in hosts with compromised immune systems. The lack of a suitable small animal model for screening anti-cryptosporidial drugs and for examining the pathogenicity and immunobiology of chronic cryptosporidosis was the impetus for this research effort.

The objectives of the present study were three-fold: to …