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The Role Of Extracellular Vesicles In Immunomodulation During Bovine Pregnancy, Amber E. Thornton
The Role Of Extracellular Vesicles In Immunomodulation During Bovine Pregnancy, Amber E. Thornton
All Graduate Theses and Dissertations, Fall 2023 to Present
During pregnancy, the maternal immune system must be altered to protect the partially non-self fetus from attack. Our previous studies show an inflammatory response in the uterus of cows carrying somatic cell nuclear transfer (SCNT), commonly known as cloned, pregnancies due to abnormalities in proteins expressed by placental trophoblast cells. Between 30 and 90 days the rate of pregnancy loss is 50-100% for SCNT compared to 2-10% for artificial insemination (AI) pregnancies. Abnormal communication between the maternal and fetal systems during placentation is a major cause of this loss. The trafficking of extracellular vesicles (EVs), membrane-bound cargo carriers, potentially represents …