Life Sciences Commons^™

Characterization Of Enterovirus D68 In A Mouse Model And Evaluation Of Antiviral Therapies, Zoe K. Taylor

All Graduate Theses and Dissertations, Fall 2023 to Present

Enterovirus D68 (EV-D68) is a virus that causes respiratory disease. Children are most commonly affected by EV-D68 but immunocompromised adults can also get infected and develop severe disease signs. In 2014, the United States experienced an unprecedented outbreak of EV-D68. Similar outbreaks were also observed in 2016, 2018 and 2022. Interestingly, few EV-D68 infections were observed in 2020, likely due to public health measures put in place to reduce the spread of another respiratory disease, coronavirus disease 2019 (COVID-19). EV-D68 is in the same virus family as polio, and one of the most concerning findings from these outbreaks is that …

Atmospheric Mercury At Storm Peak Laboratory: Development Of Methods To Calibrate Ambient Oxidized Mercury Measurements And Comparisons To A 3-D Photochemical Transport Model, Tyler Raymond Elgiar

All Graduate Theses and Dissertations, Fall 2023 to Present

Mercury (Hg) is a highly toxic metal found ubiquitously throughout the environment that has the potential to harm wildlife and human health. Human exposure to Hg can lead to symptoms such as blindness, loss of memory, ataxia, and death. Hg exposure to pregnant women and young children is of even greater concern, as high levels of Hg can hinder fetal and child development.

Hg is emitted into the atmosphere through natural and anthropogenic processes such as biomass burning and the incineration of coal, respectively. Hg exists in the atmosphere as elemental Hg (Hg⁰) or in an oxidized form …

Relative Hepatotoxocity, Carcinogenicity, And Toxicogenomics Of Select Dehydropyrrolizidine Alkaloids In Mice, Michael J. Clayton

All Graduate Theses and Dissertations, Fall 2023 to Present

Dehydropyrrolizidine alkaloids are arguably the most important plant derived toxins in terms of impact on human and animal health. Dehydropyrrolizidine alkaloids are a large group of chemically related compounds found in 3% of flowering plants worldwide. Human exposure occurs from ingestion of herbal products including teas supplements or contaminated grain. Animals are exposed through contaminated feed or grazing. There are at least 350 identified toxic PAs, from more than 6,000 plants. The toxins primarily cause liver damage, but some are proven to cause cancer. Indidvidual dehydropyrrolizidine alkaloids vary in their toxic effects. Riddelliine is the only dehydropyrrolizidine alkaloid with extensive …