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Full-Text Articles in Life Sciences
The Association Of Aerobic Fitness With Resting State Functional Connectivity And Verbal Learning And Memory In Healthy Young Adults, Kyle Joseph Jennette
The Association Of Aerobic Fitness With Resting State Functional Connectivity And Verbal Learning And Memory In Healthy Young Adults, Kyle Joseph Jennette
Theses and Dissertations
The beneficial effects of exercise and cardiopulmonary fitness on general health, quality of life, and reduction of mortality are well known in older adults. There is evidence to support the positive effects of exercise and aerobic fitness on psychiatric and neurocognitive function in children, adults, and older adults. Indeed, many studies have explored the positive effects of aerobic fitness on slowing cognitive decline associated with normal and pathological aging. However, comparatively fewer empirical studies in the literature exist to support and understand the effects of aerobic fitness on the developing brain, particularly during adolescence and young adulthood, especially as it …
Shaped By The Environment: The Influence Of Childhood Trauma Exposure, Individual Socioeconomic Position, And Neighborhood Disadvantage On Brain Morphology, Elisabeth Kathleen Webb
Shaped By The Environment: The Influence Of Childhood Trauma Exposure, Individual Socioeconomic Position, And Neighborhood Disadvantage On Brain Morphology, Elisabeth Kathleen Webb
Theses and Dissertations
The relationship between an individual’s socioeconomic position (SEP) and their overall physical and mental health has been well demonstrated. Far less is known about how area-level factors, such as neighborhood disadvantage, “get under the skin”. Previous research indicates lower SEP and childhood trauma negatively effects brain structure and function. The hippocampus, amygdala, and ventromedial prefrontal cortex (vmPFC) are particularly vulnerable to adversity. The current study investigated how individual SEP, childhood trauma, and neighborhood disadvantage impact these structures. Two-hundred and fifteen individuals were recruited from an Emergency Department in southeastern Wisconsin. Two-weeks post-traumatic injury, participants completed a structural magnetic resonance imaging …
Optogenetic Interrogation Of Hippocampal Circuit Stabilization, Laurel Watkins De Jong
Optogenetic Interrogation Of Hippocampal Circuit Stabilization, Laurel Watkins De Jong
Theses and Dissertations
Understanding the response of excitatory and inhibitory populations to varying input is vital to understanding how a brain region transforms information. Optogenetics - the combined use of optics and genetics to control the activity of proteins, provides neuroscientists with a tool to interrogate neuronal circuits with high spatio-temporal resolution and targeted cell specificity. This thesis examines the effects of optogenetic manipulations on hippocampal circuit responses. The hippocampus is a structure required for the formation and retention of episodic memories and is comprised of anatomically distinct subregions including cornu ammonis 3 (CA3) and cornu ammonis 1 (CA1). Both regions, despite differences …