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Part I: Synthesis And Biological Evaluations Of Potent Class L Selective Histone Deacetylase Inhibitors Part Ii: Aqueous Complexes For Efficient Sizebased Separation Of Americium From Curium Part Iii: Designing Strong Chiral Bronsted Acids And Their Application For Oxaxinanones Derivatization And The Aza-Henry Reaction, Joseph Steve Ulicki
Theses and Dissertations
PART I: SYNTHESIS AND BIOLOGICAL EVALUATIONS OF POTENT CLASS l SELECTIVE HISTONE DEACETYLASE INHIBITORS
Histone deacetylase inhibitors (HDACi) have found a wide variety of medicinal uses and are most noted for their specific apoptotic action towards cancer cells1. Several hydroxamates and tetrapeptides HDACi have since been moved on to phase 1 and 2 clinical trials, with FK228 & SAHA having already been approved for treatment of advanced cutaneous T-cell lymphoma (CTCL). FK228 & SAHA are pan-HDACi which d compounds describes the unselective inhibition for any of the 11 Zn2+-dependent HDAC isoforms. Research in the past five years, has shifted towards …